Duplex Stem Replacement with bPNA+ Triplex Hybrid Stems Enables Reporting on Tertiary Interactions of Internal RNA Domains.
Journal
Journal of the American Chemical Society
ISSN: 1520-5126
Titre abrégé: J Am Chem Soc
Pays: United States
ID NLM: 7503056
Informations de publication
Date de publication:
12 06 2019
12 06 2019
Historique:
pubmed:
17
5
2019
medline:
22
9
2020
entrez:
17
5
2019
Statut:
ppublish
Résumé
We report herein the synthesis and DNA/RNA binding properties of bPNA+, a new variant of bifacial peptide nucleic acid (bPNA) that binds oligo T/U nucleic acids to form triplex hybrids. By virtue of a new bivalent side chain on bPNA+, similar DNA affinity and hybrid thermostability can be obtained with half the molecular footprint of previously reported bPNA. Lysine derivatives bearing two melamine bases (K
Identifiants
pubmed: 31094510
doi: 10.1021/jacs.9b03435
pmc: PMC7043357
mid: NIHMS1069120
doi:
Substances chimiques
Peptide Nucleic Acids
0
Peptides
0
RNA
63231-63-0
DNA
9007-49-2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
9365-9372Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM111995
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM120582
Pays : United States
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