P2X receptors and trigeminal neuralgia.

Adenosine Triphosphate / metabolism Humans Pain / metabolism Purinergic P2X Receptor Antagonists / pharmacology Receptors, Purinergic P2X / drug effects Trigeminal Ganglion / metabolism Trigeminal Neuralgia / metabolism

Journal

Neuroreport
ISSN: 1473-558X
Titre abrégé: Neuroreport
Pays: England
ID NLM: 9100935

Informations de publication

Date de publication:
03 07 2019
Historique:
pubmed: 17 5 2019
medline: 12 5 2020
entrez: 17 5 2019
Statut: ppublish

Résumé

There is currently no effective cure for trigeminal neuralgia (TN) - a relatively common disease that causes long-term pain in patients. Previous research has shown that ionotropic ATP signaling through excitatory and calcium-permeable P2X receptor channels plays a critical role in pathological pain generation and maintenance. In this paper, we review several hypotheses on the pathogenic mechanisms underlying TN. We further discuss pathways or agents that can target P2X expression in TN, thereby affecting pain induction and maintenance.

Identifiants

DOI: 10.1097/WNR.0000000000001266 PMID: 31095112
pubmed: 31095112
doi: 10.1097/WNR.0000000000001266
doi:

Substances chimiques

Purinergic P2X Receptor Antagonists 0
Receptors, Purinergic P2X 0
Adenosine Triphosphate 8L70Q75FXE

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

725-729

Auteurs

Jia-Juan Li (JJ)

The Second Clinical Medical College of Nanchang University.

Zeng-Xu Liu (ZX)

Department of Anatomy, Medical School of Nanchang University, Nanchang, People's Republic of China.

Ya-Ling Zhang (YL)

Department of Anatomy, Medical School of Nanchang University, Nanchang, People's Republic of China.

Guo-Yong Xue (GY)

Department of Anatomy, Medical School of Nanchang University, Nanchang, People's Republic of China.

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Classifications MeSH

questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nucléotides adényliques › Adénosine triphosphate › P2X receptors and trigeminal neuralgia.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › P2X receptors and trigeminal neuralgia.
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Sensation › Douleur › P2X receptors and trigeminal neuralgia.
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents purinergiques › Antagonistes purinergiques › Antagonistes des récepteurs purinergiques P2 › Antagonistes des récepteurs purinergiques P2X › P2X receptors and trigeminal neuralgia.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs purinergiques › Récepteurs purinergiques P2 › Récepteurs purinergiques P2X › P2X receptors and trigeminal neuralgia.
questionsmedicales.fr › Système nerveux › Système nerveux périphérique › Nerfs périphériques › Nerfs crâniens › Nerf trijumeau › Ganglion trigéminal › P2X receptors and trigeminal neuralgia.
questionsmedicales.fr › Maladies du système nerveux › Atteintes des nerfs crâniens › Atteintes du nerf facial › Névralgie faciale › Atteintes du nerf trijumeau › Névralgie essentielle du trijumeau › P2X receptors and trigeminal neuralgia.