Tissue Factor and Cancer: Regulation, Tumor Growth, and Metastasis.
Journal
Seminars in thrombosis and hemostasis
ISSN: 1098-9064
Titre abrégé: Semin Thromb Hemost
Pays: United States
ID NLM: 0431155
Informations de publication
Date de publication:
Jun 2019
Jun 2019
Historique:
pubmed:
17
5
2019
medline:
26
11
2019
entrez:
17
5
2019
Statut:
ppublish
Résumé
There is a strong relationship between tissue factor (TF) and cancer. Many cancer cells express high levels of both full-length TF and alternatively spliced (as) TF. TF expression in cancer is associated with poor prognosis. In this review, the authors summarize the regulation of TF expression in cancer cells and the roles of TF and asTF in tumor growth and metastasis. A variety of different signaling pathways, transcription factors and micro ribonucleic acids regulate TF gene expression in cancer cells. The TF/factor VIIa complex enhances tumor growth by activating protease-activated receptor 2 signaling and by increasing the expression of angiogenic factors, such as vascular endothelial growth factor. AsTF increases tumor growth by enhancing integrin β1 signaling. TF and asTF also contribute to metastasis via multiple thrombin-dependent and independent mechanisms that include protecting tumor cells from natural killer cells. Finally, a novel anticancer therapy is using tumor TF as a target to deliver cytotoxic drugs to the tumor. TF may be useful in diagnosis, prognosis, and treatment of cancer.
Identifiants
pubmed: 31096306
doi: 10.1055/s-0039-1687894
pmc: PMC6546519
mid: NIHMS1030943
doi:
Substances chimiques
Immunoconjugates
0
Vascular Endothelial Growth Factor A
0
Thromboplastin
9035-58-9
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
385-395Subventions
Organisme : NCI NIH HHS
ID : R01 CA190717
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL007149
Pays : United States
Informations de copyright
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
Déclaration de conflit d'intérêts
Nigel Mackman is a consultant for Seattle Genetics. Yohei Hisada has no conflict of interest.
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