Time course of fluid responsiveness in sepsis: the fluid challenge revisiting (FCREV) study.
Aged
Arterial Pressure
/ drug effects
Cardiac Output
/ drug effects
Crystalloid Solutions
/ therapeutic use
Echocardiography
/ methods
Female
Fluid Therapy
/ methods
France
Humans
Intensive Care Units
/ organization & administration
Male
Middle Aged
Prospective Studies
Sepsis
/ physiopathology
Time Factors
Echocardiography
Fluid challenge
Fluid responsiveness
ICU
Shock
Journal
Critical care (London, England)
ISSN: 1466-609X
Titre abrégé: Crit Care
Pays: England
ID NLM: 9801902
Informations de publication
Date de publication:
16 05 2019
16 05 2019
Historique:
received:
05
12
2018
accepted:
17
04
2019
entrez:
18
5
2019
pubmed:
18
5
2019
medline:
20
12
2019
Statut:
epublish
Résumé
Fluid challenge (FC) is one of the most common practices in Intensive Care Unit (ICU). The present study aimed to evaluate whether echocardiographic assessment of the response to FC at the end of the infusion or 20 min later could affect the results of the FC. This is a prospective, observational, multicenter study including all ICU patients in septic shock requiring a FC of 500 mL crystalloids over 10 min. Fluid responsiveness was defined as a > 15% increase in stroke volume (SV) assessed by velocity-time integral (VTI) measurements at baseline (T From May 20, 2014, to January 7, 2016, a total of 143 patients were enrolled in 11 French ICUs (mean age 64 ± 14 years, median IGS II 53 [43-63], median SOFA score 10 [8-12]). Among the 76/143 (53%) patient responders to FC at T This study shows that 51.3% of initial responders have a persistent response to fluid 30 min after the beginning of fluid infusion and only 41.3% have a transient response highlighting that fluid responsiveness is time dependent. ClinicalTrials.gov , NCT02116413 . Registered on April 16, 2014.
Sections du résumé
BACKGROUND
Fluid challenge (FC) is one of the most common practices in Intensive Care Unit (ICU). The present study aimed to evaluate whether echocardiographic assessment of the response to FC at the end of the infusion or 20 min later could affect the results of the FC.
METHODS
This is a prospective, observational, multicenter study including all ICU patients in septic shock requiring a FC of 500 mL crystalloids over 10 min. Fluid responsiveness was defined as a > 15% increase in stroke volume (SV) assessed by velocity-time integral (VTI) measurements at baseline (T
RESULTS
From May 20, 2014, to January 7, 2016, a total of 143 patients were enrolled in 11 French ICUs (mean age 64 ± 14 years, median IGS II 53 [43-63], median SOFA score 10 [8-12]). Among the 76/143 (53%) patient responders to FC at T
CONCLUSIONS
This study shows that 51.3% of initial responders have a persistent response to fluid 30 min after the beginning of fluid infusion and only 41.3% have a transient response highlighting that fluid responsiveness is time dependent.
TRIAL REGISTRATION
ClinicalTrials.gov , NCT02116413 . Registered on April 16, 2014.
Identifiants
pubmed: 31097012
doi: 10.1186/s13054-019-2448-z
pii: 10.1186/s13054-019-2448-z
pmc: PMC6524325
doi:
Substances chimiques
Crystalloid Solutions
0
Banques de données
ClinicalTrials.gov
['NCT02116413']
Types de publication
Journal Article
Multicenter Study
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
179Investigateurs
Claire Roger
(C)
Laurent Zieleskiewicz
(L)
Karim Lakhal
(K)
Benjamin Louart
(B)
Jean-Michel Constantin
(JM)
Russell Chabanne
(R)
Jean-Sébastien Faure
(JS)
Yazine Mahjoub
(Y)
Hervé Quintard
(H)
Jean-Yves Lefrant
(JY)
Laurent Muller
(L)
Commentaires et corrections
Type : CommentIn
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