Neonatal exposure to an inflammatory cytokine, epidermal growth factor, results in the deficits of mismatch negativity in rats.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
16 05 2019
16 05 2019
Historique:
received:
23
08
2018
accepted:
30
04
2019
entrez:
18
5
2019
pubmed:
18
5
2019
medline:
21
10
2020
Statut:
epublish
Résumé
Perinatal exposure to epidermal growth factor (EGF) induces various cognitive and behavioral abnormalities after maturation in non-human animals, and is used for animal models of schizophrenia. Patients with schizophrenia often display a reduction of mismatch negativity (MMN), which is a stimulus-change specific event-related brain potential. Do the EGF model animals also exhibit the MMN reduction as schizophrenic patients do? This study addressed this question to verify the pathophysiological validity of this model. Neonatal rats received repeated administration of EGF or saline and were grown until adulthood. Employing the odd-ball paradigm of distinct tone pitches, tone-evoked electroencephalogram (EEG) components were recorded from electrodes on the auditory and frontal cortices of awake rats, referencing an electrode on the frontal sinus. The amplitude of the MMN-like potential was significantly reduced in EGF-treated rats compared with saline-injected control rats. The wavelet analysis of the EEG during a near period of tone stimulation revealed that synchronization of EEG activity, especially with beta and gamma bands, was reduced in EGF-treated rats. Results suggest that animals exposed to EGF during a perinatal period serve as a promising neurodevelopmental model of schizophrenia.
Identifiants
pubmed: 31097747
doi: 10.1038/s41598-019-43923-y
pii: 10.1038/s41598-019-43923-y
pmc: PMC6522493
doi:
Substances chimiques
Epidermal Growth Factor
62229-50-9
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
7503Références
Mol Psychiatry. 2017 Nov;22(11):1585-1593
pubmed: 28167837
Neuroreport. 2000 May 15;11(7):1515-7
pubmed: 10841368
Int J Psychophysiol. 2015 Jun;96(3):134-40
pubmed: 25911953
Neuroreport. 2004 May 19;15(7):1215-8
pubmed: 15129177
Psychophysiology. 1990 Nov;27(6):627-40
pubmed: 2100348
PLoS One. 2013 Dec 12;8(12):e82663
pubmed: 24349330
Trends Neurosci. 2009 Sep;32(9):485-95
pubmed: 19712980
Mol Psychiatry. 2003 Jan;8(1):19-29
pubmed: 12556905
J Clin Invest. 2007 Aug;117(8):2260-7
pubmed: 17671655
J Neurosci Methods. 2004 Mar 15;134(1):9-21
pubmed: 15102499
Proc Natl Acad Sci U S A. 2016 Jun 14;113(24):6755-60
pubmed: 27247381
PLoS One. 2014 Oct 21;9(10):e110892
pubmed: 25333698
Clin Neurophysiol. 2014 Jul;125(7):1459-70
pubmed: 24360131
J Neurosci. 1992 May;12(5):1688-97
pubmed: 1578263
Electroencephalogr Clin Neurophysiol. 1992 Jul;83(1):87-90
pubmed: 1376671
Int J Psychophysiol. 2015 Feb;95(2):145-55
pubmed: 24681247
Neurosci Lett. 1998 May 22;248(1):45-8
pubmed: 9665660
Sci Rep. 2017 May 23;7(1):2258
pubmed: 28536477
World J Biol Psychiatry. 2015 Sep;16(6):387-397
pubmed: 25774562
Science. 1984 Jun 8;224(4653):1107-9
pubmed: 6144184
Sci Rep. 2016 Dec 20;6:38904
pubmed: 27996015
Nat Rev Neurosci. 2010 Feb;11(2):100-13
pubmed: 20087360
J Neurophysiol. 1994 Sep;72(3):1270-7
pubmed: 7807210
Front Psychiatry. 2013 Dec 18;4:171
pubmed: 24391602
Neuroreport. 2001 Aug 8;12(11):2583-7
pubmed: 11496153
J Neurosci. 2009 Nov 4;29(44):13837-49
pubmed: 19889995
Neurosci Lett. 2013 Jun 28;547:21-5
pubmed: 23669645
Electroencephalogr Clin Neurophysiol. 1998 May;106(5):433-43
pubmed: 9680157
Biol Psychol. 2016 Apr;116:1-3
pubmed: 26896574
Acta Psychol (Amst). 1978 Jul;42(4):313-29
pubmed: 685709
Neuroreport. 2005 Mar 15;16(4):403-5
pubmed: 15729146
Nature. 1995 Nov 2;378(6552):75-8
pubmed: 7477292
Psychophysiology. 2014 Nov;51(11):1195-9
pubmed: 24981508
Front Psychol. 2011 Dec 09;2:367
pubmed: 22180747
Biol Psychol. 1979 Mar;8(2):81-136
pubmed: 465623
Biol Psychol. 2016 Apr;116:28-35
pubmed: 26196895
Clin Neurophysiol. 2018 Jan;129(1):222-231
pubmed: 29202390
Clin Neurophysiol. 2001 May;112(5):778-84
pubmed: 11336892
PLoS One. 2010 Dec 09;5(12):e14185
pubmed: 21151609
Nat Commun. 2017 Dec 15;8(1):2148
pubmed: 29247159
Neurosci Lett. 2005 Feb 21;374(3):157-60
pubmed: 15663953
Schizophr Res. 2005 Jul 1;76(1):1-23
pubmed: 15927795
J Physiol. 1996 Jun 1;493 ( Pt 2):471-84
pubmed: 8782110
Schizophr Res. 1999 Jan 11;35(2):141-56
pubmed: 9988851
Nat Rev Neurosci. 2015 Sep;16(9):535-50
pubmed: 26289573
Behav Genet. 2005 Sep;35(5):615-29
pubmed: 16184489
Schizophr Res. 2018 Jan;191:43-50
pubmed: 28385587
Neuroreport. 2001 Dec 21;12(18):4093-7
pubmed: 11742244
Neuroimage. 1999 Jan;9(1):135-44
pubmed: 9918735
J Neurosci. 2007 Sep 19;27(38):10116-27
pubmed: 17881518
Biomed Res Int. 2014;2014:697935
pubmed: 24949465
Brain Res Mol Brain Res. 1992 Dec;16(3-4):316-22
pubmed: 1337941
Biol Psychiatry. 2010 Feb 1;67(3):224-31
pubmed: 19765689
J Comp Neurol. 2002 Nov 25;453(4):345-60
pubmed: 12389207
Brain Dev. 2008 Sep;30(8):533-43
pubmed: 18313247
Eur J Neurosci. 2007 Jan;25(2):380-90
pubmed: 17284178
J Neurochem. 2017 Sep;142(6):886-900
pubmed: 28608461
J Psychiatr Res. 2011 May;45(5):699-705
pubmed: 21067772
Hum Brain Mapp. 2016 Nov;37(11):3882-3896
pubmed: 27273695
Neuroimage. 1999 Nov;10(5):620-4
pubmed: 10547339
Clin Neurophysiol. 2007 Dec;118(12):2544-90
pubmed: 17931964
JAMA Psychiatry. 2015 Aug;72(8):813-21
pubmed: 25587799
IEEE Trans Image Process. 2004 Apr;13(4):600-12
pubmed: 15376593
Eur Arch Psychiatry Clin Neurosci. 2008 Feb;258(1):10-5
pubmed: 17901998
Neuroreport. 2006 Oct 2;17(14):1561-4
pubmed: 16957608
Clin Neurophysiol. 2004 Aug;115(8):1863-74
pubmed: 15261865
PLoS One. 2013 Apr 30;8(4):e63203
pubmed: 23646197
Int J Psychophysiol. 2001 Oct;42(2):177-94
pubmed: 11587775
Psychophysiology. 1998 Jul;35(4):355-65
pubmed: 9643050