ALK2 inhibitors display beneficial effects in preclinical models of
Activin Receptors, Type I
/ antagonists & inhibitors
Administration, Oral
Animals
Antineoplastic Agents
/ pharmacokinetics
Apoptosis
/ drug effects
Brain Stem Neoplasms
/ drug therapy
Cell Line, Tumor
Cell Proliferation
Child
Diffuse Intrinsic Pontine Glioma
/ drug therapy
Drug Administration Schedule
Drug Evaluation, Preclinical
Female
Gene Expression
High-Throughput Screening Assays
Humans
Mice
Mice, SCID
Mutation
Protein Kinase Inhibitors
/ pharmacokinetics
Pyrazoles
/ pharmacokinetics
Pyridines
/ pharmacokinetics
Pyrimidines
/ pharmacokinetics
Survival Analysis
Xenograft Model Antitumor Assays
CNS cancer
Paediatric cancer
Target validation
Journal
Communications biology
ISSN: 2399-3642
Titre abrégé: Commun Biol
Pays: England
ID NLM: 101719179
Informations de publication
Date de publication:
2019
2019
Historique:
received:
05
03
2019
accepted:
08
04
2019
entrez:
18
5
2019
pubmed:
18
5
2019
medline:
18
5
2019
Statut:
epublish
Résumé
Diffuse intrinsic pontine glioma (DIPG) is a lethal childhood brainstem tumour, with a quarter of patients harbouring somatic mutations in
Identifiants
pubmed: 31098401
doi: 10.1038/s42003-019-0420-8
pii: 420
pmc: PMC6509210
doi:
Substances chimiques
Antineoplastic Agents
0
LDN 193189
0
Protein Kinase Inhibitors
0
Pyrazoles
0
Pyridines
0
Pyrimidines
0
ACVR1 protein, human
EC 2.7.11.30
Activin Receptors, Type I
EC 2.7.11.30
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Pagination
156Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Cancer Research UK
ID : C13468/A14078
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 106169/ZZ14/Z
Pays : United Kingdom
Déclaration de conflit d'intérêts
The authors declare no competing interests.
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