Antifungal Activities of 4″,6″-Disubstituted Amphiphilic Kanamycins.
Cryptococcus neoformans
SYTOXTM green
amphiphilic kanamycin
antifungal
kinetic membrane permeabilization
propidium iodide
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
16 May 2019
16 May 2019
Historique:
received:
16
04
2019
revised:
10
05
2019
accepted:
14
05
2019
entrez:
19
5
2019
pubmed:
19
5
2019
medline:
14
11
2019
Statut:
epublish
Résumé
Amphiphilic kanamycins derived from the classic antibiotic kanamycin have attracted interest due to their novel bioactivities beyond inhibition of bacteria. In this study, the recently described 4″,6″-diaryl amphiphilic kanamycins reported as inhibitors of connexin were examined for their antifungal activities. Nearly all 4″,6″-diaryl amphiphilic kanamycins tested had antifungal activities comparable to those of 4″,6″-dialkyl amphiphilic kanamycins, reported previously against several fungal strains. The minimal growth inhibitory concentrations (MICs) correlated with the degree of amphiphilicity (cLogD) of the di-substituted amphiphilic kanamycins. Using the fluorogenic dyes, SYTOX
Identifiants
pubmed: 31100822
pii: molecules24101882
doi: 10.3390/molecules24101882
pmc: PMC6571828
pii:
doi:
Substances chimiques
Antifungal Agents
0
Reactive Oxygen Species
0
Kanamycin
59-01-8
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Utah State University
ID : RC grant
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