Functional CD3
Adult
Aged
Aged, 80 and over
B7-H1 Antigen
/ immunology
Breast Neoplasms
/ immunology
CD3 Complex
/ metabolism
CD8-Positive T-Lymphocytes
/ immunology
Carcinoma, Intraductal, Noninfiltrating
/ immunology
Female
Follow-Up Studies
Humans
Lymphocytes, Tumor-Infiltrating
/ immunology
Middle Aged
Neoplasm Invasiveness
Prognosis
Programmed Cell Death 1 Receptor
/ immunology
Receptor, ErbB-2
/ metabolism
Retrospective Studies
Tumor Microenvironment
/ immunology
Breast cancer
Immune phenotype
Opal technique
PD1 immune microenvironment
T cells expression
Journal
Clinical breast cancer
ISSN: 1938-0666
Titre abrégé: Clin Breast Cancer
Pays: United States
ID NLM: 100898731
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
15
03
2019
accepted:
01
04
2019
pubmed:
19
5
2019
medline:
12
8
2020
entrez:
19
5
2019
Statut:
ppublish
Résumé
The changes in T cell subsets and programmed death ligand 1 (PD-L1) expression during the transition from ductal carcinoma in situ (DCIS) to early invasive breast cancer had not been well studied. A total of 85 DCIS patients were classified into 49 DCIS (clinical stage: Tis, noninvasive) and 36 with a minimally infiltrating lesion (MIL; < 5 mm; clinical stage: T1a). We explored the quantitative alterations of T-cell markers and PD-L1 in these groups using the Opal multi-immunohistochemistry technique. We observed increased infiltration of CD3-positive (CD3 We conclude that during the transition from DCIS to an invasive lesion, the host cytolytic T cells begin interacting with the tumor and destroy the tumor tissue, leading to an adaptive upregulation of PD-L1 and tumor protection against immune destruction.
Sections du résumé
BACKGROUND
The changes in T cell subsets and programmed death ligand 1 (PD-L1) expression during the transition from ductal carcinoma in situ (DCIS) to early invasive breast cancer had not been well studied.
PATIENTS AND METHODS
A total of 85 DCIS patients were classified into 49 DCIS (clinical stage: Tis, noninvasive) and 36 with a minimally infiltrating lesion (MIL; < 5 mm; clinical stage: T1a). We explored the quantitative alterations of T-cell markers and PD-L1 in these groups using the Opal multi-immunohistochemistry technique.
RESULTS
We observed increased infiltration of CD3-positive (CD3
CONCLUSION
We conclude that during the transition from DCIS to an invasive lesion, the host cytolytic T cells begin interacting with the tumor and destroy the tumor tissue, leading to an adaptive upregulation of PD-L1 and tumor protection against immune destruction.
Identifiants
pubmed: 31101455
pii: S1526-8209(19)30213-7
doi: 10.1016/j.clbc.2019.04.001
pii:
doi:
Substances chimiques
B7-H1 Antigen
0
CD274 protein, human
0
CD3 Complex
0
PDCD1 protein, human
0
Programmed Cell Death 1 Receptor
0
ERBB2 protein, human
EC 2.7.10.1
Receptor, ErbB-2
EC 2.7.10.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e617-e623Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.