Suicide and suicide attempts after subthalamic nucleus stimulation in Parkinson disease.

Deep Brain Stimulation / adverse effects Female Follow-Up Studies Humans Male Middle Aged Parkinson Disease / mortality Postoperative Complications / mortality Retrospective Studies Subthalamic Nucleus Suicide

Journal

Neurology
ISSN: 1526-632X
Titre abrégé: Neurology
Pays: United States
ID NLM: 0401060

Informations de publication

Date de publication:
02 07 2019
Historique:
received: 20 10 2018
accepted: 18 02 2019
pubmed: 19 5 2019
medline: 10 1 2020
entrez: 19 5 2019
Statut: ppublish

Résumé

To determine the postoperative attempted and completed suicide rates after subthalamic nucleus deep brain stimulation (STN-DBS) in a single-center cohort and to determine factors associated with attempted and completed suicide. We retrospectively included all patients with Parkinson disease (PD) who underwent bilateral STN-DBS surgery at the Grenoble University Hospital between 1993 and 2016. For each patient who committed or attempted suicide, 2 patients with PD with STN-DBS without any suicidal behaviors were matched for age (±1 year), sex, and year of surgery (±2 years). Clinical data were collected from medical records. Detailed preoperative and postoperative neuropsychological evaluations, including frontal and Beck Depression Inventory (BDI) scores, were gathered. A total of 534 patients with PD were included. Completed and attempted suicide percentages were 0.75% (4 of 534) and 4.11% (22 of 534), respectively. The observed suicide rate in the first postoperative year (187.20 of 100,000 per year, 1 of 534) was higher than the expected National Observatory on Suicide Risks rate adjusted for age and sex (standardized mortality ratio 8.1). This rate remained similar over the second and third postoperative years. In a comparison of the 26 patients completing/attempting suicide and the 52 controls, the first group showed more frequent history of suicidal ideation/suicide attempts and psychotic symptoms, higher percentage of family psychiatric history, higher psychiatric medication use, and higher preoperative frontal and BDI scores on neuropsychological evaluations. Suicide behaviors can occur after STN-DBS, especially during the first 3 years. A careful multidisciplinary assessment and long-term follow-up are recommended to recognize and treat this potentially preventable risk for mortality.

Identifiants

DOI: 10.1212/WNL.0000000000007665 PMID: 31101738
pubmed: 31101738
pii: WNL.0000000000007665
doi: 10.1212/WNL.0000000000007665
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e97-e105

Informations de copyright

© 2019 American Academy of Neurology.

Auteurs

Giulia Giannini (G)

From the IRCCS Istituto delle Scienze Neurologiche di Bologna (G.G.), UOC Clinica Neurologica; Department of Biomedical and NeuroMotor Sciences (G.G.), Alma Mater Studiorum, University of Bologna, Italy; Movement Disorders Unit (G.G., E.L., E.S., V.F., A.C., C.A., A.B., P.P., P.K., E.M.), Division of Neurology and Clinique de Psychiatrie (M.F., M.P.), Pôle Neurologie Psychiatrie, CHU of Grenoble, Grenoble Alpes University; Department of Neurosurgery (A.-L.B., E.S., S.C.), CHU of Grenoble, Grenoble Alpes University; and Department of Medical Informatics (M.W.), HEGP, AP-HP, Paris, France.

Matthieu Francois (M)

From the IRCCS Istituto delle Scienze Neurologiche di Bologna (G.G.), UOC Clinica Neurologica; Department of Biomedical and NeuroMotor Sciences (G.G.), Alma Mater Studiorum, University of Bologna, Italy; Movement Disorders Unit (G.G., E.L., E.S., V.F., A.C., C.A., A.B., P.P., P.K., E.M.), Division of Neurology and Clinique de Psychiatrie (M.F., M.P.), Pôle Neurologie Psychiatrie, CHU of Grenoble, Grenoble Alpes University; Department of Neurosurgery (A.-L.B., E.S., S.C.), CHU of Grenoble, Grenoble Alpes University; and Department of Medical Informatics (M.W.), HEGP, AP-HP, Paris, France.

Eugénie Lhommée (E)

From the IRCCS Istituto delle Scienze Neurologiche di Bologna (G.G.), UOC Clinica Neurologica; Department of Biomedical and NeuroMotor Sciences (G.G.), Alma Mater Studiorum, University of Bologna, Italy; Movement Disorders Unit (G.G., E.L., E.S., V.F., A.C., C.A., A.B., P.P., P.K., E.M.), Division of Neurology and Clinique de Psychiatrie (M.F., M.P.), Pôle Neurologie Psychiatrie, CHU of Grenoble, Grenoble Alpes University; Department of Neurosurgery (A.-L.B., E.S., S.C.), CHU of Grenoble, Grenoble Alpes University; and Department of Medical Informatics (M.W.), HEGP, AP-HP, Paris, France.

Mircea Polosan (M)

From the IRCCS Istituto delle Scienze Neurologiche di Bologna (G.G.), UOC Clinica Neurologica; Department of Biomedical and NeuroMotor Sciences (G.G.), Alma Mater Studiorum, University of Bologna, Italy; Movement Disorders Unit (G.G., E.L., E.S., V.F., A.C., C.A., A.B., P.P., P.K., E.M.), Division of Neurology and Clinique de Psychiatrie (M.F., M.P.), Pôle Neurologie Psychiatrie, CHU of Grenoble, Grenoble Alpes University; Department of Neurosurgery (A.-L.B., E.S., S.C.), CHU of Grenoble, Grenoble Alpes University; and Department of Medical Informatics (M.W.), HEGP, AP-HP, Paris, France.

Emmanuelle Schmitt (E)

From the IRCCS Istituto delle Scienze Neurologiche di Bologna (G.G.), UOC Clinica Neurologica; Department of Biomedical and NeuroMotor Sciences (G.G.), Alma Mater Studiorum, University of Bologna, Italy; Movement Disorders Unit (G.G., E.L., E.S., V.F., A.C., C.A., A.B., P.P., P.K., E.M.), Division of Neurology and Clinique de Psychiatrie (M.F., M.P.), Pôle Neurologie Psychiatrie, CHU of Grenoble, Grenoble Alpes University; Department of Neurosurgery (A.-L.B., E.S., S.C.), CHU of Grenoble, Grenoble Alpes University; and Department of Medical Informatics (M.W.), HEGP, AP-HP, Paris, France.

Valérie Fraix (V)

From the IRCCS Istituto delle Scienze Neurologiche di Bologna (G.G.), UOC Clinica Neurologica; Department of Biomedical and NeuroMotor Sciences (G.G.), Alma Mater Studiorum, University of Bologna, Italy; Movement Disorders Unit (G.G., E.L., E.S., V.F., A.C., C.A., A.B., P.P., P.K., E.M.), Division of Neurology and Clinique de Psychiatrie (M.F., M.P.), Pôle Neurologie Psychiatrie, CHU of Grenoble, Grenoble Alpes University; Department of Neurosurgery (A.-L.B., E.S., S.C.), CHU of Grenoble, Grenoble Alpes University; and Department of Medical Informatics (M.W.), HEGP, AP-HP, Paris, France.

Anna Castrioto (A)

From the IRCCS Istituto delle Scienze Neurologiche di Bologna (G.G.), UOC Clinica Neurologica; Department of Biomedical and NeuroMotor Sciences (G.G.), Alma Mater Studiorum, University of Bologna, Italy; Movement Disorders Unit (G.G., E.L., E.S., V.F., A.C., C.A., A.B., P.P., P.K., E.M.), Division of Neurology and Clinique de Psychiatrie (M.F., M.P.), Pôle Neurologie Psychiatrie, CHU of Grenoble, Grenoble Alpes University; Department of Neurosurgery (A.-L.B., E.S., S.C.), CHU of Grenoble, Grenoble Alpes University; and Department of Medical Informatics (M.W.), HEGP, AP-HP, Paris, France.

Claire Ardouin (C)

From the IRCCS Istituto delle Scienze Neurologiche di Bologna (G.G.), UOC Clinica Neurologica; Department of Biomedical and NeuroMotor Sciences (G.G.), Alma Mater Studiorum, University of Bologna, Italy; Movement Disorders Unit (G.G., E.L., E.S., V.F., A.C., C.A., A.B., P.P., P.K., E.M.), Division of Neurology and Clinique de Psychiatrie (M.F., M.P.), Pôle Neurologie Psychiatrie, CHU of Grenoble, Grenoble Alpes University; Department of Neurosurgery (A.-L.B., E.S., S.C.), CHU of Grenoble, Grenoble Alpes University; and Department of Medical Informatics (M.W.), HEGP, AP-HP, Paris, France.

Amélie Bichon (A)

From the IRCCS Istituto delle Scienze Neurologiche di Bologna (G.G.), UOC Clinica Neurologica; Department of Biomedical and NeuroMotor Sciences (G.G.), Alma Mater Studiorum, University of Bologna, Italy; Movement Disorders Unit (G.G., E.L., E.S., V.F., A.C., C.A., A.B., P.P., P.K., E.M.), Division of Neurology and Clinique de Psychiatrie (M.F., M.P.), Pôle Neurologie Psychiatrie, CHU of Grenoble, Grenoble Alpes University; Department of Neurosurgery (A.-L.B., E.S., S.C.), CHU of Grenoble, Grenoble Alpes University; and Department of Medical Informatics (M.W.), HEGP, AP-HP, Paris, France.

Pierre Pollak (P)

From the IRCCS Istituto delle Scienze Neurologiche di Bologna (G.G.), UOC Clinica Neurologica; Department of Biomedical and NeuroMotor Sciences (G.G.), Alma Mater Studiorum, University of Bologna, Italy; Movement Disorders Unit (G.G., E.L., E.S., V.F., A.C., C.A., A.B., P.P., P.K., E.M.), Division of Neurology and Clinique de Psychiatrie (M.F., M.P.), Pôle Neurologie Psychiatrie, CHU of Grenoble, Grenoble Alpes University; Department of Neurosurgery (A.-L.B., E.S., S.C.), CHU of Grenoble, Grenoble Alpes University; and Department of Medical Informatics (M.W.), HEGP, AP-HP, Paris, France.

Alim-Louis Benabid (AL)

From the IRCCS Istituto delle Scienze Neurologiche di Bologna (G.G.), UOC Clinica Neurologica; Department of Biomedical and NeuroMotor Sciences (G.G.), Alma Mater Studiorum, University of Bologna, Italy; Movement Disorders Unit (G.G., E.L., E.S., V.F., A.C., C.A., A.B., P.P., P.K., E.M.), Division of Neurology and Clinique de Psychiatrie (M.F., M.P.), Pôle Neurologie Psychiatrie, CHU of Grenoble, Grenoble Alpes University; Department of Neurosurgery (A.-L.B., E.S., S.C.), CHU of Grenoble, Grenoble Alpes University; and Department of Medical Informatics (M.W.), HEGP, AP-HP, Paris, France.

Eric Seigneuret (E)

From the IRCCS Istituto delle Scienze Neurologiche di Bologna (G.G.), UOC Clinica Neurologica; Department of Biomedical and NeuroMotor Sciences (G.G.), Alma Mater Studiorum, University of Bologna, Italy; Movement Disorders Unit (G.G., E.L., E.S., V.F., A.C., C.A., A.B., P.P., P.K., E.M.), Division of Neurology and Clinique de Psychiatrie (M.F., M.P.), Pôle Neurologie Psychiatrie, CHU of Grenoble, Grenoble Alpes University; Department of Neurosurgery (A.-L.B., E.S., S.C.), CHU of Grenoble, Grenoble Alpes University; and Department of Medical Informatics (M.W.), HEGP, AP-HP, Paris, France.

Stephan Chabardes (S)

From the IRCCS Istituto delle Scienze Neurologiche di Bologna (G.G.), UOC Clinica Neurologica; Department of Biomedical and NeuroMotor Sciences (G.G.), Alma Mater Studiorum, University of Bologna, Italy; Movement Disorders Unit (G.G., E.L., E.S., V.F., A.C., C.A., A.B., P.P., P.K., E.M.), Division of Neurology and Clinique de Psychiatrie (M.F., M.P.), Pôle Neurologie Psychiatrie, CHU of Grenoble, Grenoble Alpes University; Department of Neurosurgery (A.-L.B., E.S., S.C.), CHU of Grenoble, Grenoble Alpes University; and Department of Medical Informatics (M.W.), HEGP, AP-HP, Paris, France.

Maxime Wack (M)

From the IRCCS Istituto delle Scienze Neurologiche di Bologna (G.G.), UOC Clinica Neurologica; Department of Biomedical and NeuroMotor Sciences (G.G.), Alma Mater Studiorum, University of Bologna, Italy; Movement Disorders Unit (G.G., E.L., E.S., V.F., A.C., C.A., A.B., P.P., P.K., E.M.), Division of Neurology and Clinique de Psychiatrie (M.F., M.P.), Pôle Neurologie Psychiatrie, CHU of Grenoble, Grenoble Alpes University; Department of Neurosurgery (A.-L.B., E.S., S.C.), CHU of Grenoble, Grenoble Alpes University; and Department of Medical Informatics (M.W.), HEGP, AP-HP, Paris, France.

Paul Krack (P)

From the IRCCS Istituto delle Scienze Neurologiche di Bologna (G.G.), UOC Clinica Neurologica; Department of Biomedical and NeuroMotor Sciences (G.G.), Alma Mater Studiorum, University of Bologna, Italy; Movement Disorders Unit (G.G., E.L., E.S., V.F., A.C., C.A., A.B., P.P., P.K., E.M.), Division of Neurology and Clinique de Psychiatrie (M.F., M.P.), Pôle Neurologie Psychiatrie, CHU of Grenoble, Grenoble Alpes University; Department of Neurosurgery (A.-L.B., E.S., S.C.), CHU of Grenoble, Grenoble Alpes University; and Department of Medical Informatics (M.W.), HEGP, AP-HP, Paris, France.

Elena Moro (E)

From the IRCCS Istituto delle Scienze Neurologiche di Bologna (G.G.), UOC Clinica Neurologica; Department of Biomedical and NeuroMotor Sciences (G.G.), Alma Mater Studiorum, University of Bologna, Italy; Movement Disorders Unit (G.G., E.L., E.S., V.F., A.C., C.A., A.B., P.P., P.K., E.M.), Division of Neurology and Clinique de Psychiatrie (M.F., M.P.), Pôle Neurologie Psychiatrie, CHU of Grenoble, Grenoble Alpes University; Department of Neurosurgery (A.-L.B., E.S., S.C.), CHU of Grenoble, Grenoble Alpes University; and Department of Medical Informatics (M.W.), HEGP, AP-HP, Paris, France. elenamfmoro@gmail.com.

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Classifications MeSH

questionsmedicales.fr › Procédures de chirurgie opératoire › Stimulation cérébrale profonde › Suicide and suicide attempts after subthalamic...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études de suivi › Suicide and suicide attempts after subthalamic...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Suicide and suicide attempts after subthalamic...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Suicide and suicide attempts after subthalamic...
questionsmedicales.fr › Maladies du système nerveux › Maladies neurodégénératives › Maladie de Parkinson › Suicide and suicide attempts after subthalamic...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Complications postopératoires › Suicide and suicide attempts after subthalamic...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études rétrospectives › Suicide and suicide attempts after subthalamic...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Diencéphale › Subthalamus › Noyau subthalamique › Suicide and suicide attempts after subthalamic...
questionsmedicales.fr › Sciences sociales › Sociologie › Problèmes sociaux › Suicide › Suicide and suicide attempts after subthalamic...