Complete sequence of human T cell leukemia virus type 1 in ATLL patients from Northeast Iran, Mashhad revealed a prematurely terminated protease and an elongated pX open reading frame III.
Amino Acid Sequence
Base Sequence
Brazil
Canada
China
DNA, Viral
/ genetics
Female
France
Genes, Viral
/ genetics
Germany
Human T-lymphotropic virus 1
/ genetics
Humans
Iran
Japan
Leukemia-Lymphoma, Adult T-Cell
/ virology
Male
Middle Aged
Open Reading Frames
/ genetics
Peptide Hydrolases
/ genetics
Repetitive Sequences, Nucleic Acid
/ genetics
Transcription Factors
/ genetics
Viral Regulatory and Accessory Proteins
/ genetics
ATLL
DNA sequencing
HTLV-1
Nucleotide variations
Journal
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
ISSN: 1567-7257
Titre abrégé: Infect Genet Evol
Pays: Netherlands
ID NLM: 101084138
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
received:
31
01
2019
revised:
03
05
2019
accepted:
14
05
2019
pubmed:
19
5
2019
medline:
2
4
2020
entrez:
19
5
2019
Statut:
ppublish
Résumé
To gain insight into the origin, evolution, dissemination and viral factors affecting HTLV-1-associated diseases, knowing the complete viral genome sequences is important. So far, no full-length HTLV-1 genome sequence has been reported from Iran. Here we report the complete nucleotide sequence of HTLV-1 viruses isolated from adult T cell leukemia/lymphoma (ATLL) patients from this region. The genome size of HTLV-1-MhD (Mashhad) was found to be 9036 bp and sequence analysis of the LTR region showed that it belongs to cosmopolitan subtype A. Comparing the sequences with isolates from another endemic area (HTLV-1ATK) revealed variations in the U3 region (~3.4%), while there was 99.1% and 97.0% similarity in R and U5 regions, respectively. The nucleotide sequences of HTLV-1 gag, pro and pol genes had a difference of 1.1% compared with HTLV-1 ATK with 16 nucleotides replaced in the gag and 27 in the pol regions. There was no variability in the amino acid sequences in the p24
Identifiants
pubmed: 31102740
pii: S1567-1348(19)30090-5
doi: 10.1016/j.meegid.2019.05.012
pii:
doi:
Substances chimiques
DNA, Viral
0
Transcription Factors
0
Viral Regulatory and Accessory Proteins
0
pX protein, Human T-lymphotropic virus 1
0
Peptide Hydrolases
EC 3.4.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
460-469Informations de copyright
Copyright © 2019. Published by Elsevier B.V.