Forced oscillation measurements in the first week of life and pulmonary outcome in very preterm infants on noninvasive respiratory support.
Academic Medical Centers
Body Size
Female
Gestational Age
Humans
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases
/ therapy
Infant, Very Low Birth Weight
Intensive Care, Neonatal
Lung
/ physiopathology
Lung Compliance
Male
Multivariate Analysis
Oscillometry
Prospective Studies
Respiration, Artificial
/ methods
Respiratory Function Tests
Respiratory Mechanics
Sample Size
Surface-Active Agents
/ therapeutic use
Switzerland
Journal
Pediatric research
ISSN: 1530-0447
Titre abrégé: Pediatr Res
Pays: United States
ID NLM: 0100714
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
received:
07
02
2019
accepted:
11
05
2019
revised:
11
04
2019
pubmed:
21
5
2019
medline:
20
8
2020
entrez:
21
5
2019
Statut:
ppublish
Résumé
We aimed at investigating whether early lung mechanics in non-intubated infants below 32 weeks of gestational age (GA) are associated with respiratory outcome. Lung mechanics were assessed by the forced oscillation technique using a mechanical ventilator (Fabian HFOi, ACUTRONIC Medical Systems AG, Hirzel, Switzerland) that superimposed small-amplitude oscillations (10 Hz) on a continuous positive airway pressure. Measurements were performed during regular tidal breathing using a face mask on days 2, 4, and 7 of life. Respiratory system resistance (Rrs) and reactance (Xrs) were computed from flow and pressure. One hundred and seventy-seven measurements were successfully performed in 68 infants. Infants had a mean (range) GA of 29.3 (24.1-31.7) weeks and a birth weight of 1257 (670-2350)g. Xrs was associated with the duration of respiratory support (R Assessment of Xrs in the first week of life is feasible and improves prognostication of respiratory outcome in very preterm infants on noninvasive respiratory support.
Sections du résumé
BACKGROUND
We aimed at investigating whether early lung mechanics in non-intubated infants below 32 weeks of gestational age (GA) are associated with respiratory outcome.
METHODS
Lung mechanics were assessed by the forced oscillation technique using a mechanical ventilator (Fabian HFOi, ACUTRONIC Medical Systems AG, Hirzel, Switzerland) that superimposed small-amplitude oscillations (10 Hz) on a continuous positive airway pressure. Measurements were performed during regular tidal breathing using a face mask on days 2, 4, and 7 of life. Respiratory system resistance (Rrs) and reactance (Xrs) were computed from flow and pressure.
RESULTS
One hundred and seventy-seven measurements were successfully performed in 68 infants. Infants had a mean (range) GA of 29.3 (24.1-31.7) weeks and a birth weight of 1257 (670-2350)g. Xrs was associated with the duration of respiratory support (R
CONCLUSION
Assessment of Xrs in the first week of life is feasible and improves prognostication of respiratory outcome in very preterm infants on noninvasive respiratory support.
Identifiants
pubmed: 31108499
doi: 10.1038/s41390-019-0432-6
pii: 10.1038/s41390-019-0432-6
doi:
Substances chimiques
Surface-Active Agents
0
Types de publication
Journal Article
Observational Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM