Pharmacological Targeting of the ER-Resident Chaperones GRP94 or Cyclophilin B Induces Secretion of IL-22 Binding Protein Isoform-1 (IL-22BPi1).
Benzoquinones
/ pharmacology
Binding Sites
/ drug effects
Cyclophilins
/ chemistry
Cyclosporine
/ pharmacology
Endoplasmic Reticulum
/ metabolism
Endoplasmic Reticulum Chaperone BiP
Gene Expression Profiling
Glycosylation
HEK293 Cells
Humans
Lactams, Macrocyclic
/ pharmacology
Membrane Glycoproteins
/ chemistry
Monocytes
/ metabolism
Protein Binding
/ drug effects
Protein Isoforms
/ chemistry
Proteolysis
Receptors, Interleukin
/ chemistry
BiP
ER
GRP78
GRP94
IL-22BP
IL22RA2
UPR
cyclophilin
cyclosporin A
geldanamycin
gp96
isoform
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
17 May 2019
17 May 2019
Historique:
received:
29
04
2019
revised:
14
05
2019
accepted:
15
05
2019
entrez:
22
5
2019
pubmed:
22
5
2019
medline:
13
11
2019
Statut:
epublish
Résumé
Of the three interleukin-22 binding protein (IL-22BP) isoforms produced by the human
Identifiants
pubmed: 31108847
pii: ijms20102440
doi: 10.3390/ijms20102440
pmc: PMC6566634
pii:
doi:
Substances chimiques
Benzoquinones
0
Endoplasmic Reticulum Chaperone BiP
0
HSPA5 protein, human
0
IL22RA2 protein, human
0
Lactams, Macrocyclic
0
Membrane Glycoproteins
0
Protein Isoforms
0
Receptors, Interleukin
0
endoplasmin
0
cyclophilin B
137497-17-7
Cyclosporine
83HN0GTJ6D
Cyclophilins
EC 5.2.1.-
geldanamycin
Z3K3VJ16KU
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Osasun Saila, Eusko Jaurlaritzako
ID : IT512-10, PPG17/44
Organisme : Ministerio de Economía y Competitividad
ID : SAF2016-74891R
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