TAS-120 Overcomes Resistance to ATP-Competitive FGFR Inhibitors in Patients with FGFR2 Fusion-Positive Intrahepatic Cholangiocarcinoma.
Adenosine Triphosphate
/ metabolism
Adult
Aged
Cell Line, Tumor
Cholangiocarcinoma
/ diagnosis
Circulating Tumor DNA
Drug Resistance, Neoplasm
/ genetics
Female
Humans
Male
Middle Aged
Mutation
Oncogene Proteins, Fusion
/ antagonists & inhibitors
Phenylurea Compounds
/ pharmacology
Protein Kinase Inhibitors
/ chemistry
Pyrimidines
/ pharmacology
Receptor, Fibroblast Growth Factor, Type 2
/ antagonists & inhibitors
Signal Transduction
/ drug effects
Structure-Activity Relationship
Tomography, X-Ray Computed
Journal
Cancer discovery
ISSN: 2159-8290
Titre abrégé: Cancer Discov
Pays: United States
ID NLM: 101561693
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
received:
13
02
2019
revised:
16
04
2019
accepted:
15
05
2019
pubmed:
22
5
2019
medline:
6
8
2020
entrez:
22
5
2019
Statut:
ppublish
Résumé
ATP-competitive fibroblast growth factor receptor (FGFR) kinase inhibitors, including BGJ398 and Debio 1347, show antitumor activity in patients with intrahepatic cholangiocarcinoma (ICC) harboring activating
Identifiants
pubmed: 31109923
pii: 2159-8290.CD-19-0182
doi: 10.1158/2159-8290.CD-19-0182
pmc: PMC6677584
mid: NIHMS1530014
doi:
Substances chimiques
Circulating Tumor DNA
0
Oncogene Proteins, Fusion
0
Phenylurea Compounds
0
Protein Kinase Inhibitors
0
Pyrimidines
0
Adenosine Triphosphate
8L70Q75FXE
infigratinib
A4055ME1VK
FGFR2 protein, human
EC 2.7.10.1
Receptor, Fibroblast Growth Factor, Type 2
EC 2.7.10.1
Types de publication
Case Reports
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
1064-1079Subventions
Organisme : NCI NIH HHS
ID : U01 CA224146
Pays : United States
Organisme : NCI NIH HHS
ID : K08 CA194268
Pays : United States
Organisme : NIGMS NIH HHS
ID : P50 GM107618
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA176058
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA208437
Pays : United States
Organisme : NCI NIH HHS
ID : U54 CA224068
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA127003
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA199253
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA235412
Pays : United States
Informations de copyright
©2019 American Association for Cancer Research.
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