Sequence environment of BMP-dependent activating elements controls transcriptional responses to Dpp signaling in


Journal

Development (Cambridge, England)
ISSN: 1477-9129
Titre abrégé: Development
Pays: England
ID NLM: 8701744

Informations de publication

Date de publication:
12 06 2019
Historique:
received: 23 01 2019
accepted: 14 05 2019
pubmed: 22 5 2019
medline: 1 7 2020
entrez: 22 5 2019
Statut: epublish

Résumé

Intercellular signaling pathways activate transcription factors, which, along with tissue-specific co-factors, regulate expression of target genes. Responses to TGFβ/BMP signals are mediated by Smad proteins, which form complexes and accumulate in the nucleus to directly bind and regulate enhancers of BMP targets upon signaling. In

Identifiants

pubmed: 31110028
pii: dev.176107
doi: 10.1242/dev.176107
pii:
doi:

Substances chimiques

Bone Morphogenetic Proteins 0
Drosophila Proteins 0
Receptors, Cell Surface 0
dpp protein, Drosophila 0
wit protein, Drosophila 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2019. Published by The Company of Biologists Ltd.

Déclaration de conflit d'intérêts

Competing interestsThe authors declare no competing or financial interests.

Auteurs

Mrinal Chayengia (M)

Signalling Research Centres BIOSS and CIBSS, Albert-Ludwigs-University of Freiburg, 79104 Freiburg, Germany.
Research Training Program GRK 1104, Albert-Ludwigs-University of Freiburg, 79104 Freiburg, Germany.
Institute for Biology I, Faculty of Biology, Albert-Ludwigs-University of Freiburg, Germany.

Ville Veikkolainen (V)

Signalling Research Centres BIOSS and CIBSS, Albert-Ludwigs-University of Freiburg, 79104 Freiburg, Germany.
Institute for Biology I, Faculty of Biology, Albert-Ludwigs-University of Freiburg, Germany.

Milica Jevtic (M)

Institute for Biology I, Faculty of Biology, Albert-Ludwigs-University of Freiburg, Germany.
Spemann Graduate School of Biology and Medicine (SGBM), Albert-Ludwigs-University of Freiburg, 79104 Freiburg, Germany.

George Pyrowolakis (G)

Signalling Research Centres BIOSS and CIBSS, Albert-Ludwigs-University of Freiburg, 79104 Freiburg, Germany g.pyrowolakis@biologie.uni-freiburg.de.
Institute for Biology I, Faculty of Biology, Albert-Ludwigs-University of Freiburg, Germany.
Center for Biological Systems Analysis, Albert-Ludwigs-University of Freiburg, Habsburgerstr. 49, 79104 Freiburg, Germany.

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Classifications MeSH