Serial C-Reactive Protein Measurements in Newborn Infants without Evidence of Early-Onset Infection.
C-reactive protein
Negative blood culture
Newborn
Postnatal
Journal
Neonatology
ISSN: 1661-7819
Titre abrégé: Neonatology
Pays: Switzerland
ID NLM: 101286577
Informations de publication
Date de publication:
2019
2019
Historique:
received:
02
10
2018
accepted:
25
01
2019
pubmed:
22
5
2019
medline:
22
5
2020
entrez:
22
5
2019
Statut:
ppublish
Résumé
C-reactive protein (CRP) is used to assist the diagnosis and monitoring of newborn infection. Little is known about CRP activity after birth in the absence of infection. The aim of this work was to describe postnatal CRP responses in the first days of life in asymptomatic infants with a negative blood culture. Data were collected from infants who had a blood culture taken at <72 h of age in a UK maternity hospital. All CRP values and their time from birth were recorded. Infants with signs of infection, positive blood culture, or major congenital anomalies were excluded. Infants were analysed by gestation (greater or less than 37 weeks). Normalised CRP curves were generated by linear interpolation and centile curves were derived. Comparisons of median CRP values between groups were made by Mann-Whitney U test at 24, 36, and 48 h. During the study period a total of 219 babies were screened. After exclusions, 73 infants (58 term, 15 preterm) were analysed. In asymptomatic term neonates the CRP (mg/L) peaked at 9.4 after 34.6 h. In preterm babies the CRP peak was 1.75 at 43 h. The median (IQR) values were higher in the term group at 24 and 36 h: 2.5 (1-10.5) versus 0 (0-2.2; p = 0.02) and 3 (0-8.6) versus 0 (0-2.8; p = 0.031). A CRP rise was demonstrated in term and preterm infants without evidence of infection. This rise was greatest in term infants. CRP values must be interpreted in the context of an infant's clinical condition and not used alone to guide clinical decision making.
Sections du résumé
BACKGROUND
C-reactive protein (CRP) is used to assist the diagnosis and monitoring of newborn infection. Little is known about CRP activity after birth in the absence of infection.
OBJECTIVE
The aim of this work was to describe postnatal CRP responses in the first days of life in asymptomatic infants with a negative blood culture.
METHODS
Data were collected from infants who had a blood culture taken at <72 h of age in a UK maternity hospital. All CRP values and their time from birth were recorded. Infants with signs of infection, positive blood culture, or major congenital anomalies were excluded. Infants were analysed by gestation (greater or less than 37 weeks). Normalised CRP curves were generated by linear interpolation and centile curves were derived. Comparisons of median CRP values between groups were made by Mann-Whitney U test at 24, 36, and 48 h.
RESULTS
During the study period a total of 219 babies were screened. After exclusions, 73 infants (58 term, 15 preterm) were analysed. In asymptomatic term neonates the CRP (mg/L) peaked at 9.4 after 34.6 h. In preterm babies the CRP peak was 1.75 at 43 h. The median (IQR) values were higher in the term group at 24 and 36 h: 2.5 (1-10.5) versus 0 (0-2.2; p = 0.02) and 3 (0-8.6) versus 0 (0-2.8; p = 0.031).
CONCLUSIONS
A CRP rise was demonstrated in term and preterm infants without evidence of infection. This rise was greatest in term infants. CRP values must be interpreted in the context of an infant's clinical condition and not used alone to guide clinical decision making.
Identifiants
pubmed: 31112949
pii: 000497237
doi: 10.1159/000497237
doi:
Substances chimiques
C-Reactive Protein
9007-41-4
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
85-91Informations de copyright
© 2019 S. Karger AG, Basel.