Comparison of a frailty short interview to a validated frailty index in adults hospitalized for acute respiratory illness.
Acute Disease
Adolescent
Adult
Aged
Aged, 80 and over
Female
Frailty
/ diagnosis
Hospitalization
/ statistics & numerical data
Humans
Influenza Vaccines
/ administration & dosage
Influenza, Human
/ prevention & control
Linear Models
Male
Medical Records
Middle Aged
Respiratory Tract Diseases
/ complications
Vaccination
Young Adult
Adults
Frailty
Hospitalization
Influenza
Influenza vaccination
Journal
Vaccine
ISSN: 1873-2518
Titre abrégé: Vaccine
Pays: Netherlands
ID NLM: 8406899
Informations de publication
Date de publication:
27 06 2019
27 06 2019
Historique:
received:
17
12
2018
revised:
15
04
2019
accepted:
15
05
2019
pubmed:
23
5
2019
medline:
29
9
2020
entrez:
23
5
2019
Statut:
ppublish
Résumé
Frailty is an important physiologic factor in studies of influenza and influenza vaccines carried out in older adults and hospitalized populations. Unfortunately, comprehensive assessments of frailty requiring physical assessments and extensive medical record review are not often feasible in time- and resource-limited settings common to studies of influenza and influenza vaccines. We developed a 5-question frailty short interview, and implemented it in a multicenter, hospital-based study of influenza over two years. Frailty status defined by the frailty short interview was compared to a validated frailty index based on medical record review of 59 parameters. Agreement between the two frailty measures was assessed, and multivariable linear regression models were used to explore differences between the measures. The association between each frailty measure and likelihood of influenza vaccination was also assessed. During the 2015-2016 and 2016-2017 influenza seasons, 2070 adult patients hospitalized with acute respiratory illness were enrolled and included in analyses. Frailty was frequently identified in the study population; 43% of participants were defined as frail by the frailty short interview and 32% by frailty index. Responses to the frailty short interview were only moderately correlated with the frailty index, and agreement between the two frailty measures was low. Women were more likely to be defined as frail by the frailty short interview than men. White individuals were more likely than other races to be defined as frail by the frailty index. Increasing frailty index was associated with increased likelihood of influenza vaccination, but the frailty short interview was not associated with vaccination. The frailty short interview provided a feasible and consistent measure of frailty across study hospitals and study years. However, its modest correlation with the frailty index and differential association with likelihood of influenza vaccination highlight differences in the conceptualization of frailty.
Sections du résumé
BACKGROUND
Frailty is an important physiologic factor in studies of influenza and influenza vaccines carried out in older adults and hospitalized populations. Unfortunately, comprehensive assessments of frailty requiring physical assessments and extensive medical record review are not often feasible in time- and resource-limited settings common to studies of influenza and influenza vaccines.
METHODS
We developed a 5-question frailty short interview, and implemented it in a multicenter, hospital-based study of influenza over two years. Frailty status defined by the frailty short interview was compared to a validated frailty index based on medical record review of 59 parameters. Agreement between the two frailty measures was assessed, and multivariable linear regression models were used to explore differences between the measures. The association between each frailty measure and likelihood of influenza vaccination was also assessed.
RESULTS
During the 2015-2016 and 2016-2017 influenza seasons, 2070 adult patients hospitalized with acute respiratory illness were enrolled and included in analyses. Frailty was frequently identified in the study population; 43% of participants were defined as frail by the frailty short interview and 32% by frailty index. Responses to the frailty short interview were only moderately correlated with the frailty index, and agreement between the two frailty measures was low. Women were more likely to be defined as frail by the frailty short interview than men. White individuals were more likely than other races to be defined as frail by the frailty index. Increasing frailty index was associated with increased likelihood of influenza vaccination, but the frailty short interview was not associated with vaccination.
CONCLUSIONS
The frailty short interview provided a feasible and consistent measure of frailty across study hospitals and study years. However, its modest correlation with the frailty index and differential association with likelihood of influenza vaccination highlight differences in the conceptualization of frailty.
Identifiants
pubmed: 31113675
pii: S0264-410X(19)30686-3
doi: 10.1016/j.vaccine.2019.05.051
pmc: PMC8564875
mid: NIHMS1751882
pii:
doi:
Substances chimiques
Influenza Vaccines
0
Types de publication
Comparative Study
Journal Article
Multicenter Study
Research Support, U.S. Gov't, P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
3849-3855Subventions
Organisme : NCIRD CDC HHS
ID : U01 IP000974
Pays : United States
Organisme : NCIRD CDC HHS
ID : U01 IP000979
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.
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