A single tyrosine phosphorylation site in cortactin is important for filopodia formation in neuronal growth cones.

Actin-Related Protein 2-3 Complex / metabolism Animals Aplysia / metabolism Cell Membrane / metabolism Cortactin / metabolism Growth Cones / metabolism Neurons / metabolism Phosphorylation Phosphotyrosine / metabolism Pseudopodia / metabolism Recombinant Proteins / metabolism Signal Transduction src-Family Kinases / metabolism

Journal

Molecular biology of the cell
ISSN: 1939-4586
Titre abrégé: Mol Biol Cell
Pays: United States
ID NLM: 9201390

Informations de publication

Date de publication:
15 07 2019
Historique:
pubmed: 23 5 2019
medline: 14 1 2020
entrez: 23 5 2019
Statut: ppublish

Résumé

Cortactin is a Src tyrosine phosphorylation substrate that regulates multiple actin-related cellular processes. While frequently studied in nonneuronal cells, the functions of cortactin in neuronal growth cones are not well understood. We recently reported that cortactin mediates the effects of Src tyrosine kinase in regulating actin organization and dynamics in both lamellipodia and filopodia of

Identifiants

DOI: 10.1091/mbc.E18-04-0202 PMID: 31116646 PMC: PMC6727743
pubmed: 31116646
doi: 10.1091/mbc.E18-04-0202
pmc: PMC6727743
doi:

Substances chimiques

Actin-Related Protein 2-3 Complex 0
Cortactin 0
Recombinant Proteins 0
Phosphotyrosine 21820-51-9
src-Family Kinases EC 2.7.10.2

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

1817-1833

Subventions

Organisme : NIGMS NIH HHS
ID : R01 GM100092
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM119785
Pays : United States

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Auteurs

Yuan Ren (Y)

Department of Biological Sciences, Purdue University, West Lafayette, IN 47907.

Yingpei He (Y)

Department of Biological Sciences, Purdue University, West Lafayette, IN 47907.

Sherlene Brown (S)

Department of Biochemistry, Purdue University, West Lafayette, IN 47907.

Erica Zbornik (E)

Department of Biological Sciences, Purdue University, West Lafayette, IN 47907.

Michael J Mlodzianoski (MJ)

Department of Weldon School of Biomedical Engineering, Purdue Institutes of Inflammation, Immunology and Infectious Disease, Purdue University, West Lafayette, IN 47907.

Donghan Ma (D)

Department of Weldon School of Biomedical Engineering, Purdue Institutes of Inflammation, Immunology and Infectious Disease, Purdue University, West Lafayette, IN 47907.

Fang Huang (F)

Department of Weldon School of Biomedical Engineering, Purdue Institutes of Inflammation, Immunology and Infectious Disease, Purdue University, West Lafayette, IN 47907.
Department of Inflammation, Immunology and Infectious Disease, Purdue University, West Lafayette, IN 47907.
Department of Integrative Neuroscience, Purdue University, West Lafayette, IN 47907.

Seema Mattoo (S)

Department of Biological Sciences, Purdue University, West Lafayette, IN 47907.
Department of Inflammation, Immunology and Infectious Disease, Purdue University, West Lafayette, IN 47907.

Daniel M Suter (DM)

Department of Biological Sciences, Purdue University, West Lafayette, IN 47907.
Department of Integrative Neuroscience, Purdue University, West Lafayette, IN 47907.
Department of Bindley Bioscience Center, Purdue University, West Lafayette, IN 47907.
Department of Birck Nanotechnology Center, Purdue University, West Lafayette, IN 47907.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du cytosquelette › Protéines des microfilaments › Complexe Arp-2-3 › A single tyrosine phosphorylation site in...
questionsmedicales.fr › Eucaryotes › Animaux › A single tyrosine phosphorylation site in...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Mollusca › Gastropoda › Aplysia › A single tyrosine phosphorylation site in...
questionsmedicales.fr › Cellules › Structures cellulaires › Membrane cellulaire › A single tyrosine phosphorylation site in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Phosphoprotéines › Cortactine › A single tyrosine phosphorylation site in...
questionsmedicales.fr › Cellules › Neurones › Neurofibres › Axones › Cônes de croissance › A single tyrosine phosphorylation site in...
questionsmedicales.fr › Cellules › Neurones › A single tyrosine phosphorylation site in...
questionsmedicales.fr › Métabolisme › Phosphorylation › A single tyrosine phosphorylation site in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides phosphoaminés › Phosphotyrosine › A single tyrosine phosphorylation site in...
questionsmedicales.fr › Cellules › Structures cellulaires › Prolongements cytoplasmiques › Pseudopodes › A single tyrosine phosphorylation site in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines recombinantes › A single tyrosine phosphorylation site in...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › A single tyrosine phosphorylation site in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-tyrosine kinases › src-Family kinases › A single tyrosine phosphorylation site in...