The cytoskeletal crosslinking protein MACF1 is dispensable for thrombus formation and hemostasis.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
22 05 2019
22 05 2019
Historique:
received:
01
02
2019
accepted:
27
04
2019
entrez:
24
5
2019
pubmed:
24
5
2019
medline:
23
10
2020
Statut:
epublish
Résumé
Coordinated reorganization of cytoskeletal structures is critical for key aspects of platelet physiology. While several studies have addressed the role of microtubules and filamentous actin in platelet production and function, the significance of their crosstalk in these processes has been poorly investigated. The microtubule-actin cross-linking factor 1 (MACF1; synonym: Actin cross-linking factor 7, ACF7) is a member of the spectraplakin family, and one of the few proteins expressed in platelets, which possess actin and microtubule binding domains thereby facilitating actin-microtubule interaction and regulation. We used megakaryocyte- and platelet-specific Macf1 knockout (Macf1
Identifiants
pubmed: 31118482
doi: 10.1038/s41598-019-44183-6
pii: 10.1038/s41598-019-44183-6
pmc: PMC6531446
doi:
Substances chimiques
Macf1 protein, mouse
0
Microfilament Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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