Estimating the burden of α-thalassaemia in Thailand using a comprehensive prevalence database for Southeast Asia.
Thalassaemia
epidemiology
genetic diversity
global health
human
newborn prevalence
spatial distribution
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
23 05 2019
23 05 2019
Historique:
received:
08
08
2018
accepted:
01
05
2019
entrez:
24
5
2019
pubmed:
24
5
2019
medline:
19
2
2020
Statut:
epublish
Résumé
Severe forms of α-thalassaemia, haemoglobin H disease and haemoglobin Bart's hydrops fetalis, are an important public health concern in Southeast Asia. Yet information on the prevalence, genetic diversity and health burden of α-thalassaemia in the region remains limited. We compiled a geodatabase of α-thalassaemia prevalence and genetic diversity surveys and, using geostatistical modelling methods, generated the first continuous maps of α-thalassaemia mutations in Thailand and sub-national estimates of the number of newborns with severe forms in 2020. We also summarised the current evidence-base for α-thalassaemia prevalence and diversity for the region. We estimate that 3595 (95% credible interval 1,717-6,199) newborns will be born with severe α-thalassaemia in Thailand in 2020, which is considerably higher than previous estimates. Accurate, fine-scale epidemiological data are necessary to guide sustainable national and regional health policies for α-thalassaemia management. Our maps and newborn estimates are an important first step towards this aim. This article has been through an editorial process in which the authors decide how to respond to the issues raised during peer review. The Reviewing Editor's assessment is that all the issues have been addressed (see decision letter).
Identifiants
pubmed: 31120421
doi: 10.7554/eLife.40580
pii: 40580
pmc: PMC6533055
doi:
pii:
Substances chimiques
Hemoglobins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : European Research Council
ID : 268904
Pays : International
Organisme : Medical Research Council
ID : MR/R015600/1
Pays : United Kingdom
Informations de copyright
© 2019, Hockham et al.
Déclaration de conflit d'intérêts
CH, SE, SB, BP, SG, VV, FP No competing interests declared
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