Effects of brain training on brain blood flow (The Cognition and Flow Study-CogFlowS): protocol for a feasibility randomised controlled trial of cognitive training in dementia.
Activities of Daily Living
Affect
Alzheimer Disease
/ diagnostic imaging
Brain
/ blood supply
Cerebrovascular Circulation
Cognition
Cognitive Dysfunction
/ diagnostic imaging
Dementia
/ diagnostic imaging
Feasibility Studies
Functional Neuroimaging
Humans
Quality of Life
Software
Therapy, Computer-Assisted
Ultrasonography, Doppler, Transcranial
alzheimer’s disease
cerebral haemodynamics
cognitive impairment
mild cognitive impairment
neuroimaging
transcranial doppler ultrasonography
Journal
BMJ open
ISSN: 2044-6055
Titre abrégé: BMJ Open
Pays: England
ID NLM: 101552874
Informations de publication
Date de publication:
22 05 2019
22 05 2019
Historique:
entrez:
25
5
2019
pubmed:
28
5
2019
medline:
30
5
2020
Statut:
epublish
Résumé
Cognitive training is an emerging non-pharmacological treatment to improve cognitive and physical function in mild cognitive impairment (MCI) and early Alzheimer's disease (AD). Abnormal brain blood flow is a key process in the development of cognitive decline. However, no studies have explored the effects of cognitive training on brain blood flow in dementia. The primary aim of this study is to assess the feasibility for a large-scale, randomised controlled trial of cognitive training in healthy older adults (HC), MCI and early AD. This study will recruit 60 participants, in three subgroups of 20 (MCI, HC, AD), from primary, secondary and community services. Participants will be randomised to a 12-week computerised cognitive training programme (five × 30 min sessions per week), or waiting-list control. Participants will undergo baseline and follow-up assessments of: mood, cognition, quality of life and activities of daily living. Cerebral blood flow will be measured at rest and during task activation (pretraining and post-training) by bilateral transcranial Doppler ultrasonography, alongside heart rate (3-lead ECG), end-tidal CO Bradford Leeds Research Ethics committee awarded a favourable opinion (18/YH/0396). Results of the study will be published in peer-reviewed journals, and presented at national and international conferences on ageing and dementia. NCT03656107; Pre-results.
Identifiants
pubmed: 31122994
pii: bmjopen-2018-027817
doi: 10.1136/bmjopen-2018-027817
pmc: PMC6538045
doi:
Banques de données
ClinicalTrials.gov
['NCT03656107']
Types de publication
Clinical Trial Protocol
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e027817Informations de copyright
© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
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