Utility of Plasma Concentration of Trimethylamine N-Oxide in Predicting Cardiovascular and Renal Complications in Individuals With Type 1 Diabetes.
Aged
Biomarkers
/ blood
Diabetes Mellitus, Type 1
/ blood
Diabetic Cardiomyopathies
/ etiology
Diabetic Nephropathies
/ etiology
Female
Gastrointestinal Microbiome
Glomerular Filtration Rate
Humans
Kidney
/ physiopathology
Kidney Failure, Chronic
/ etiology
Male
Methylamines
/ blood
Middle Aged
Myocardial Infarction
/ etiology
Proportional Hazards Models
Prospective Studies
Renal Insufficiency
/ etiology
Risk Factors
Stroke
/ etiology
Journal
Diabetes care
ISSN: 1935-5548
Titre abrégé: Diabetes Care
Pays: United States
ID NLM: 7805975
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
received:
08
01
2019
accepted:
25
04
2019
pubmed:
28
5
2019
medline:
25
4
2020
entrez:
25
5
2019
Statut:
ppublish
Résumé
Trimethylamine N-oxide (TMAO) is suggested as an independent gut microbiota-derived risk factor for cardiovascular and renal disease. We investigated associations between plasma TMAO concentrations and cardio-renal outcomes in a prospective study of individuals with type 1 diabetes. Plasma TMAO was measured at baseline in 1,159 individuals with type 1 diabetes (58% male, mean ± SD age 46 ± 13 years). End points were all-cause and cardiovascular mortality, cardiovascular disease (CVD), and renal events tracked from national registries. Associations between TMAO and end points were tested using Cox regression models. After 15.0 (6.7-19.3) (median [interquartile range]) years of follow-up, we recorded all-cause and cardiovascular mortality ( In individuals with type 1 diabetes, higher concentrations of plasma TMAO were associated with mortality, CVD events, and poor renal outcome, independent of conventional risk factors. However, the association became insignificant after further adjustment for baseline eGFR. This could reflect TMAO as a renal function marker or a risk factor for micro- and macrovascular complications mediated through impaired renal function.
Identifiants
pubmed: 31123156
pii: dc19-0048
doi: 10.2337/dc19-0048
pmc: PMC7082641
doi:
Substances chimiques
Biomarkers
0
Methylamines
0
trimethyloxamine
FLD0K1SJ1A
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1512-1520Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK106000
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL103866
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL126827
Pays : United States
Informations de copyright
© 2019 by the American Diabetes Association.
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