BRAF inhibition sensitizes melanoma cells to α-amanitin via decreased RNA polymerase II assembly.


Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
23 05 2019
Historique:
received: 26 11 2018
accepted: 08 05 2019
entrez: 25 5 2019
pubmed: 28 5 2019
medline: 21 10 2020
Statut: epublish

Résumé

Despite the great success of small molecule inhibitors in the treatment of patients with BRAF

Identifiants

pubmed: 31123282
doi: 10.1038/s41598-019-44112-7
pii: 10.1038/s41598-019-44112-7
pmc: PMC6533289
doi:

Substances chimiques

Alpha-Amanitin 0
Nucleic Acid Synthesis Inhibitors 0
BRAF protein, human EC 2.7.11.1
Proto-Oncogene Proteins B-raf EC 2.7.11.1
RNA Polymerase II EC 2.7.7.-

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

7779

Références

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Auteurs

Lukas Frischknecht (L)

Institute of Molecular Health Sciences, ETH Zurich, 8093, Zurich, Switzerland.

Christian Britschgi (C)

Institute of Molecular Health Sciences, ETH Zurich, 8093, Zurich, Switzerland.
Department of Medical Oncology and Hematology, University Hospital of Zurich and University of Zurich, 8091, Zurich, Switzerland.

Patricia Galliker (P)

Institute of Molecular Health Sciences, ETH Zurich, 8093, Zurich, Switzerland.

Yann Christinat (Y)

Institute of Molecular Health Sciences, ETH Zurich, 8093, Zurich, Switzerland.

Anton Vichalkovski (A)

Institute of Molecular Systems Biology, ETH Zurich, 8093, Zurich, Switzerland.

Matthias Gstaiger (M)

Institute of Molecular Systems Biology, ETH Zurich, 8093, Zurich, Switzerland.

Werner J Kovacs (WJ)

Institute of Molecular Health Sciences, ETH Zurich, 8093, Zurich, Switzerland. werner.kovacs@biol.ethz.ch.

Wilhelm Krek (W)

Institute of Molecular Health Sciences, ETH Zurich, 8093, Zurich, Switzerland.

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Classifications MeSH