Immune homeostasis and regulation of the interferon pathway require myeloid-derived Regnase-3.
3' Untranslated Regions
Animals
Autoimmunity
B-Lymphocytes
/ metabolism
Flow Cytometry
Gene Expression Regulation
Homeostasis
/ immunology
Immunity, Innate
Interferons
/ metabolism
Macrophages
/ metabolism
Mice
Mice, Inbred C57BL
Mice, Knockout
Myeloid Cells
/ enzymology
Real-Time Polymerase Chain Reaction
Ribonucleases
/ genetics
Signal Transduction
T-Lymphocytes
/ metabolism
Journal
The Journal of experimental medicine
ISSN: 1540-9538
Titre abrégé: J Exp Med
Pays: United States
ID NLM: 2985109R
Informations de publication
Date de publication:
01 07 2019
01 07 2019
Historique:
received:
16
09
2018
revised:
15
02
2019
accepted:
12
04
2019
pubmed:
28
5
2019
medline:
23
6
2020
entrez:
26
5
2019
Statut:
ppublish
Résumé
The RNase Regnase-1 is a master RNA regulator in macrophages and T cells that degrades cellular and viral RNA upon NF-κB signaling. The roles of its family members, however, remain largely unknown. Here, we analyzed
Identifiants
pubmed: 31126966
pii: jem.20181762
doi: 10.1084/jem.20181762
pmc: PMC6605757
doi:
Substances chimiques
3' Untranslated Regions
0
Interferons
9008-11-1
Ribonucleases
EC 3.1.-
Zc3h12c protein, mouse
EC 3.1.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1700-1723Informations de copyright
© 2019 von Gamm et al.
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