Atlas of group A streptococcal vaccine candidates compiled using large-scale comparative genomics.

Antigens, Bacterial / genetics Genome, Bacterial Genome-Wide Association Study Genomics / methods Humans Phylogeny Recombination, Genetic Streptococcal Infections / prevention & control Streptococcal Vaccines / genetics Streptococcus pyogenes / classification

Journal

Nature genetics
ISSN: 1546-1718
Titre abrégé: Nat Genet
Pays: United States
ID NLM: 9216904

Informations de publication

Date de publication:
06 2019
Historique:
received: 16 05 2018
accepted: 10 04 2019
pubmed: 28 5 2019
medline: 10 7 2019
entrez: 29 5 2019
Statut: ppublish

Résumé

Group A Streptococcus (GAS; Streptococcus pyogenes) is a bacterial pathogen for which a commercial vaccine for humans is not available. Employing the advantages of high-throughput DNA sequencing technology to vaccine design, we have analyzed 2,083 globally sampled GAS genomes. The global GAS population structure reveals extensive genomic heterogeneity driven by homologous recombination and overlaid with high levels of accessory gene plasticity. We identified the existence of more than 290 clinically associated genomic phylogroups across 22 countries, highlighting challenges in designing vaccines of global utility. To determine vaccine candidate coverage, we investigated all of the previously described GAS candidate antigens for gene carriage and gene sequence heterogeneity. Only 15 of 28 vaccine antigen candidates were found to have both low naturally occurring sequence variation and high (>99%) coverage across this diverse GAS population. This technological platform for vaccine coverage determination is equally applicable to prospective GAS vaccine antigens identified in future studies.

Identifiants

DOI: 10.1038/s41588-019-0417-8 PMID: 31133745 PMC: PMC6650292
pubmed: 31133745
doi: 10.1038/s41588-019-0417-8
pii: 10.1038/s41588-019-0417-8
pmc: PMC6650292
mid: EMS83447
doi:

Substances chimiques

Antigens, Bacterial 0
Streptococcal Vaccines 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1035-1043

Subventions

Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 098051
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 206194
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/R015600/1
Pays : United Kingdom

Commentaires et corrections

Type : ErratumIn

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Auteurs

Mark R Davies (MR)

Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne and The Royal Melbourne Hospital, Melbourne, Victoria, Australia. mark.davies1@unimelb.edu.au.
The Wellcome Trust Sanger Institute, Hinxton, UK. mark.davies1@unimelb.edu.au.
School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland, Australia. mark.davies1@unimelb.edu.au.
Australian Infectious Diseases Research Centre, The University of Queensland, Brisbane, Queensland, Australia. mark.davies1@unimelb.edu.au.
ORCID: 0000-0001-6141-5179

Liam McIntyre (L)

Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne and The Royal Melbourne Hospital, Melbourne, Victoria, Australia.

Ankur Mutreja (A)

The Wellcome Trust Sanger Institute, Hinxton, UK.
GSK Vaccines Institute for Global Health, Siena, Italy.

Jake A Lacey (JA)

Doherty Department, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne and The Royal Melbourne Hospital, Melbourne, Victoria, Australia.

John A Lees (JA)

Department of Microbiology, New York University School of Medicine, New York, NY, USA.

Rebecca J Towers (RJ)

Menzies School of Health Research, Darwin, Northern Territory, Australia.

Sebastián Duchêne (S)

Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne and The Royal Melbourne Hospital, Melbourne, Victoria, Australia.
Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia.

Pierre R Smeesters (PR)

Molecular Bacteriology Laboratory, Université Libre de Bruxelles, Brussels, Belgium.
Department of Pediatrics, Queen Fabiola Childrens University Hospital, Université Libre de Bruxelles, Brussels, Belgium.
Murdoch Childrens Research Institute, Melbourne, Victoria, Australia.

Hannah R Frost (HR)

Molecular Bacteriology Laboratory, Université Libre de Bruxelles, Brussels, Belgium.
Department of Pediatrics, Queen Fabiola Childrens University Hospital, Université Libre de Bruxelles, Brussels, Belgium.
Murdoch Childrens Research Institute, Melbourne, Victoria, Australia.
ORCID: 0000-0002-1543-2805

David J Price (DJ)

Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.
Victorian Infectious Diseases Reference Laboratory Epidemiology Unit, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne and The Royal Melbourne Hospital, Melbourne, Victoria, Australia.
ORCID: 0000-0003-0076-3123

Matthew T G Holden (MTG)

The Wellcome Trust Sanger Institute, Hinxton, UK.
School of Medicine, University of St Andrews, St Andrews, UK.
ORCID: 0000-0002-4958-2166

Sophia David (S)

The Wellcome Trust Sanger Institute, Hinxton, UK.

Philip M Giffard (PM)

Menzies School of Health Research, Darwin, Northern Territory, Australia.

Kate A Worthing (KA)

Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne and The Royal Melbourne Hospital, Melbourne, Victoria, Australia.

Anna C Seale (AC)

Wellcome Trust Research Centre, Kilifi, Kenya.

James A Berkley (JA)

Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
ORCID: 0000-0002-1236-849X

Simon R Harris (SR)

The Wellcome Trust Sanger Institute, Hinxton, UK.

Tania Rivera-Hernandez (T)

School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland, Australia.
Australian Infectious Diseases Research Centre, The University of Queensland, Brisbane, Queensland, Australia.

Olga Berking (O)

School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland, Australia.
Australian Infectious Diseases Research Centre, The University of Queensland, Brisbane, Queensland, Australia.

Amanda J Cork (AJ)

School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland, Australia.
Australian Infectious Diseases Research Centre, The University of Queensland, Brisbane, Queensland, Australia.

Rosângela S L A Torres (RSLA)

Laboratory of Bacteriology, Epidemiology Laboratory and Disease Control Division, Laboratório Central do Estado do Paraná, Curitiba, Brazil.
Department of Medicine, Universidade Positivo, Curitiba, Brazil.

Trevor Lithgow (T)

Infection and Immunity Program, Biomedicine Discovery Institute and Department of Microbiology, Monash University, Melbourne, Victoria, Australia.

Richard A Strugnell (RA)

Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne and The Royal Melbourne Hospital, Melbourne, Victoria, Australia.
ORCID: 0000-0003-0614-5641

Rene Bergmann (R)

Helmholtz Centre for Infection Research, Braunschweig, Germany.

Patric Nitsche-Schmitz (P)

Helmholtz Centre for Infection Research, Braunschweig, Germany.

Gusharan S Chhatwal (GS)

Helmholtz Centre for Infection Research, Braunschweig, Germany.

Stephen D Bentley (SD)

The Wellcome Trust Sanger Institute, Hinxton, UK.

John D Fraser (JD)

Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.

Nicole J Moreland (NJ)

Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.

Jonathan R Carapetis (JR)

Telethon Kids Institute, University of Western Australia and Perth Children's Hospital, Perth, Western Australia, Australia.

Andrew C Steer (AC)

Murdoch Childrens Research Institute, Melbourne, Victoria, Australia.

Julian Parkhill (J)

The Wellcome Trust Sanger Institute, Hinxton, UK.
ORCID: 0000-0002-7069-5958

Allan Saul (A)

GSK Vaccines Institute for Global Health, Siena, Italy.

Deborah A Williamson (DA)

Microbiological Diagnostic Unit Public Health Laboratory, Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne and The Royal Melbourne Hospital, Melbourne, Victoria, Australia.

Bart J Currie (BJ)

Menzies School of Health Research, Darwin, Northern Territory, Australia.

Steven Y C Tong (SYC)

Doherty Department, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne and The Royal Melbourne Hospital, Melbourne, Victoria, Australia.
Menzies School of Health Research, Darwin, Northern Territory, Australia.
Victorian Infectious Disease Service, The Royal Melbourne Hospital, Melbourne, Victoria, Australia.

Gordon Dougan (G)

The Wellcome Trust Sanger Institute, Hinxton, UK.
Department of Medicine, University of Cambridge, Cambridge, UK.

Mark J Walker (MJ)

School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland, Australia. mark.walker@uq.edu.au.
Australian Infectious Diseases Research Centre, The University of Queensland, Brisbane, Queensland, Australia. mark.walker@uq.edu.au.
ORCID: 0000-0001-7423-2769

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Classifications MeSH

questionsmedicales.fr › Facteurs biologiques › Antigènes › Antigènes bactériens › Atlas of group A streptococcal vaccine...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Génome microbien › Génome bactérien › Atlas of group A streptococcal vaccine...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Épidémiologie moléculaire › Étude d'association pangénomique › Atlas of group A streptococcal vaccine...
questionsmedicales.fr › Disciplines des sciences naturelles › Disciplines des sciences biologiques › Biologie › Génétique › Génomique › Atlas of group A streptococcal vaccine...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Atlas of group A streptococcal vaccine...
questionsmedicales.fr › Sciences de l'information › Phylogenèse › Atlas of group A streptococcal vaccine...
questionsmedicales.fr › Phénomènes génétiques › Recombinaison génétique › Atlas of group A streptococcal vaccine...
questionsmedicales.fr › Infection › Infections bactériennes et mycoses › Infections bactériennes › Infections bactériennes à Gram positif › Infections à streptocoques › Atlas of group A streptococcal vaccine...
questionsmedicales.fr › Mélanges complexes › Produits biologiques › Vaccins › Vaccins antibactériens › Vaccins antistreptococciques › Atlas of group A streptococcal vaccine...
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Lactobacillales › Streptococcaceae › Streptococcus › Streptococcus pyogenes › Atlas of group A streptococcal vaccine...