E3 Ubiquitin Ligase TRIM Proteins, Cell Cycle and Mitosis.
Autophagy
Cell Cycle Checkpoints
Centrosome
/ metabolism
Chromosome Segregation
Gene Expression
Humans
Kinetochores
/ metabolism
Mitosis
/ physiology
Neoplasms
/ genetics
Spindle Poles
/ metabolism
Tripartite Motif Proteins
/ genetics
Ubiquitin
/ metabolism
Ubiquitin-Protein Ligases
/ metabolism
Ubiquitination
TRIMs
cancer
cell cycle
mitosis
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
27 05 2019
27 05 2019
Historique:
received:
03
05
2019
revised:
22
05
2019
accepted:
23
05
2019
entrez:
30
5
2019
pubmed:
30
5
2019
medline:
30
5
2019
Statut:
epublish
Résumé
The cell cycle is a series of events by which cellular components are accurately segregated into daughter cells, principally controlled by the oscillating activities of cyclin-dependent kinases (CDKs) and their co-activators. In eukaryotes, DNA replication is confined to a discrete synthesis phase while chromosome segregation occurs during mitosis. During mitosis, the chromosomes are pulled into each of the two daughter cells by the coordination of spindle microtubules, kinetochores, centromeres, and chromatin. These four functional units tie chromosomes to the microtubules, send signals to the cells when the attachment is completed and the division can proceed, and withstand the force generated by pulling the chromosomes to either daughter cell. Protein ubiquitination is a post-translational modification that plays a central role in cellular homeostasis. E3 ubiquitin ligases mediate the transfer of ubiquitin to substrate proteins determining their fate. One of the largest subfamilies of E3 ubiquitin ligases is the family of the tripartite motif (TRIM) proteins, whose dysregulation is associated with a variety of cellular processes and directly involved in human diseases and cancer. In this review we summarize the current knowledge and emerging concepts about TRIMs and their contribution to the correct regulation of cell cycle, describing how TRIMs control the cell cycle transition phases and their involvement in the different functional units of the mitotic process, along with implications in cancer progression.
Identifiants
pubmed: 31137886
pii: cells8050510
doi: 10.3390/cells8050510
pmc: PMC6562728
pii:
doi:
Substances chimiques
Tripartite Motif Proteins
0
Ubiquitin
0
Ubiquitin-Protein Ligases
EC 2.3.2.27
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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