West Nile virus infection in individuals with pre-existing Usutu virus immunity, northern Italy, 2018.
Adult
Animals
Antibodies, Neutralizing
/ blood
Antibodies, Viral
/ blood
Culex
/ virology
Disease Outbreaks
Enzyme-Linked Immunosorbent Assay
Female
Flavivirus
/ genetics
Humans
Immunoglobulin G
/ blood
Italy
/ epidemiology
Male
Middle Aged
Neutralization Tests
Phylogeny
Polymerase Chain Reaction
Public Health Surveillance
Real-Time Polymerase Chain Reaction
West Nile Fever
/ diagnosis
West Nile virus
/ genetics
Usutu virus
West Nile virus
antibody cross-reactivity
cross-protection
secondary infection
Journal
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin
ISSN: 1560-7917
Titre abrégé: Euro Surveill
Pays: Sweden
ID NLM: 100887452
Informations de publication
Date de publication:
May 2019
May 2019
Historique:
entrez:
30
5
2019
pubmed:
30
5
2019
medline:
28
7
2020
Statut:
ppublish
Résumé
In 2018, there was a large West Nile virus (WNV) outbreak in northern Italy. We observed five atypical cases of WNV infection that were characterised by the presence of WNV RNA and WNV IgG at the time of diagnosis, but no IgM response during follow-up. Neutralisation assays demonstrated pre-existing Usutu virus immunity in all patients. Besides challenging diagnosis, the immunological crosstalk between the two viruses warrants further investigation on possible cross-protection or infection enhancement effects.
Identifiants
pubmed: 31138361
doi: 10.2807/1560-7917.ES.2019.24.21.1900261
pmc: PMC6540647
doi:
Substances chimiques
Antibodies, Neutralizing
0
Antibodies, Viral
0
Immunoglobulin G
0
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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