Mono-/polyintoxication with 5F-ADB: A case series.

Adolescent Adult Cannabinoids / analysis Confusion / chemically induced Designer Drugs / analysis Driving Under the Influence Fatal Outcome Female Hair / chemistry Humans Male Middle Aged Molecular Structure Self-Injurious Behavior / chemically induced Substance Abuse Detection Unconsciousness / chemically induced
5F-ADB DUID Intoxication Synthetic cannabinoids

Journal

Forensic science international
ISSN: 1872-6283
Titre abrégé: Forensic Sci Int
Pays: Ireland
ID NLM: 7902034

Informations de publication

Date de publication:
Aug 2019
Historique:
received: 03 04 2019
revised: 16 04 2019
accepted: 08 05 2019
pubmed: 30 5 2019
medline: 17 7 2019
entrez: 30 5 2019
Statut: ppublish

Résumé

5F-ADB is an indazole-based synthetic cannabinoid. In recent years, it has been detected in legal high products as well as in biological samples and is associated with serious adverse health, behavioral effects and even death. Due to the fast pace of the market of synthetic cannabinoids, data on such newly appearing substances are scarce. As pharmacological properties are often investigated in vitro or by using animal experiments, reports on synthetic cannabinoid findings in human samples along with corresponding case history descriptions are valuable for the interpretation of upcoming routine cases. Herein we report five cases with verified 5F-ADB consumption, including three fatalities, a case of driving under the influence of drugs as well as a case of grievous bodily harm. In four cases, 5F-ADB could be detected in blood or plasma. Concentrations were in the range of 0.11-0.57 μg/L. In one instance 5F-ADB consumption was verified by the detection of 5F-ADB metabolites in postmortem body fluids. The described cases illustrate various adverse effects including confusion (possibly even psychosis), collapse, loss of consciousness, unsafe driving style or changing moods that might be attributed to 5F-ADB.

Identifiants

DOI: 10.1016/j.forsciint.2019.05.017 PMID: 31138461
pubmed: 31138461
pii: S0379-0738(19)30202-6
doi: 10.1016/j.forsciint.2019.05.017
pii:
doi:

Substances chimiques

Cannabinoids 0
Designer Drugs 0
5F-ADB cannabinoid UN52BPP7RB

Types de publication

Case Reports Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e29-e37

Informations de copyright

Copyright © 2019 Elsevier B.V. All rights reserved.

Auteurs

Michael Kraemer (M)

University of Bonn, Institute of Forensic Medicine, Forensic Toxicology, Stiftsplatz 12, 53111 Bonn, Germany. Electronic address: michael.kraemer@uni-bonn.de.

Helena Fels (H)

Forensic Toxicological Center (FTC), Bayerstraße 53, 80335 Munich, Germany. Electronic address: h.fels@ftc-muenchen.de.

Torsten Dame (T)

Forensic Toxicological Center (FTC), Bayerstraße 53, 80335 Munich, Germany. Electronic address: t.dame@ftc-muenchen.de.

Frank Musshoff (F)

Forensic Toxicological Center (FTC), Bayerstraße 53, 80335 Munich, Germany. Electronic address: f.musshoff@ftc-muenchen.de.

Sebastian Halter (S)

Institute of Forensic Medicine, Forensic Toxicology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Albertstr. 9, 79104 Freiburg, Germany; Hermann Staudinger Graduate School, University of Freiburg, Hebelstr. 27, 79104 Freiburg, Germany. Electronic address: sebastian.halter@uniklinik-freiburg.de.

Lukas Mogler (L)

Institute of Forensic Medicine, Forensic Toxicology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Albertstr. 9, 79104 Freiburg, Germany; Hermann Staudinger Graduate School, University of Freiburg, Hebelstr. 27, 79104 Freiburg, Germany. Electronic address: lukas.mogler@uniklinik-freiburg.de.

Cornelius Hess (C)

University of Mainz, Institute of Forensic Medicine, Forensic Toxicology, Am Pulverturm 3, 55131 Mainz, Germany. Electronic address: hess@uni-mainz.de.

Burkhard Madea (B)

University of Bonn, Institute of Forensic Medicine, Forensic Toxicology, Stiftsplatz 12, 53111 Bonn, Germany. Electronic address: b.madea@uni-bonn.de.

Alexandra Maas (A)

University of Bonn, Institute of Forensic Medicine, Forensic Toxicology, Stiftsplatz 12, 53111 Bonn, Germany. Electronic address: alexandramaas@uni-bonn.de.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adolescent › Mono-/polyintoxication with 5F-ADB: A case series.
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Mono-/polyintoxication with 5F-ADB: A case series.
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Terpènes › Cannabinoïdes › Mono-/polyintoxication with 5F-ADB: A case series.
questionsmedicales.fr › Comportement et mécanismes comportementaux › Manifestations neurocomportementales › Confusion › Mono-/polyintoxication with 5F-ADB: A case series.
questionsmedicales.fr › Préparations pharmaceutiques › Médicaments de synthèse › Drogues fabriquées clandestinement › Mono-/polyintoxication with 5F-ADB: A case series.
questionsmedicales.fr › Activités humaines › Conduite automobile › Conduite avec facultés affaiblies › Mono-/polyintoxication with 5F-ADB: A case series.
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Registre civil › Mortalité › Issue fatale › Mono-/polyintoxication with 5F-ADB: A case series.
questionsmedicales.fr › Système tégumentaire › Poils › Mono-/polyintoxication with 5F-ADB: A case series.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Mono-/polyintoxication with 5F-ADB: A case series.
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Mono-/polyintoxication with 5F-ADB: A case series.
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Mono-/polyintoxication with 5F-ADB: A case series.
questionsmedicales.fr › Comportement et mécanismes comportementaux › Comportement › Symptômes comportementaux › Comportement auto-agressif › Mono-/polyintoxication with 5F-ADB: A case series.
questionsmedicales.fr › Environnement et santé publique › Santé publique › Pratiques en santé publique › Dépistage de masse › Détection d'abus de substances › Mono-/polyintoxication with 5F-ADB: A case series.
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations neurologiques › Perte de conscience › Mono-/polyintoxication with 5F-ADB: A case series.