NF-κB/c-Rel deficiency causes Parkinson's disease-like prodromal symptoms and progressive pathology in mice.
NF-κB/c-Rel
Parkinson’s disease
non-motor symptoms
pathology progression
α-synuclein
Journal
Translational neurodegeneration
ISSN: 2047-9158
Titre abrégé: Transl Neurodegener
Pays: England
ID NLM: 101591861
Informations de publication
Date de publication:
2019
2019
Historique:
received:
25
09
2018
accepted:
24
04
2019
entrez:
30
5
2019
pubmed:
30
5
2019
medline:
30
5
2019
Statut:
epublish
Résumé
Parkinson's disease (PD), the most common neurodegenerative movement disorder, is characterized by dopaminergic nigrostriatal neuron loss and brain accumulation of Lewy bodies, protein aggregates mainly composed of α-synuclein. We reported that mice deficient for NF-κB/c-Rel (c-rel Intestinal and olfactory functions, intestine and brain α-synuclein deposition as well as striatal alterations, were assessed in c-rel From 2 months of age, c-rel In c-rel
Sections du résumé
BACKGROUND
BACKGROUND
Parkinson's disease (PD), the most common neurodegenerative movement disorder, is characterized by dopaminergic nigrostriatal neuron loss and brain accumulation of Lewy bodies, protein aggregates mainly composed of α-synuclein. We reported that mice deficient for NF-κB/c-Rel (c-rel
METHODS
METHODS
Intestinal and olfactory functions, intestine and brain α-synuclein deposition as well as striatal alterations, were assessed in c-rel
RESULTS
RESULTS
From 2 months of age, c-rel
CONCLUSIONS
CONCLUSIONS
In c-rel
Identifiants
pubmed: 31139367
doi: 10.1186/s40035-019-0154-z
pii: 154
pmc: PMC6530198
doi:
Types de publication
Journal Article
Langues
eng
Pagination
16Déclaration de conflit d'intérêts
Competing interestsThe authors declare that they have no competing interests.
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