Targeting Mobilization of Ferrous Iron in
Amidohydrolases
/ antagonists & inhibitors
Animals
Anti-Bacterial Agents
/ chemistry
Enzyme Inhibitors
/ chemistry
Female
Ferrous Compounds
/ chemistry
Gram-Negative Bacteria
/ drug effects
Host-Pathogen Interactions
/ drug effects
Hydroxamic Acids
/ metabolism
Lung
/ microbiology
Mice
Prodrugs
/ administration & dosage
Pseudomonas aeruginosa
/ drug effects
Respiratory Tract Infections
/ drug therapy
caged antibiotics
host−pathogen interaction
iron acquisition
nutrient acquisition
targeted prodrugs
tissue targeting
Journal
ACS infectious diseases
ISSN: 2373-8227
Titre abrégé: ACS Infect Dis
Pays: United States
ID NLM: 101654580
Informations de publication
Date de publication:
09 08 2019
09 08 2019
Historique:
pubmed:
30
5
2019
medline:
23
7
2020
entrez:
30
5
2019
Statut:
ppublish
Résumé
Iron is essential to all life, and competition for this vital nutrient is central to host-pathogen interactions during infection. The opportunistic Gram-negative pathogen
Identifiants
pubmed: 31140267
doi: 10.1021/acsinfecdis.9b00057
pmc: PMC6880962
mid: NIHMS1059121
doi:
Substances chimiques
Anti-Bacterial Agents
0
Enzyme Inhibitors
0
Ferrous Compounds
0
Hydroxamic Acids
0
Prodrugs
0
Amidohydrolases
EC 3.5.-
LpxC deacetylase, Pseudomonas
EC 3.5.1.-
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1366-1375Subventions
Organisme : NIAID NIH HHS
ID : R01 AI101171
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI105106
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM064337
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL094296
Pays : United States
Références
Nat Rev Drug Discov. 2014 Dec;13(12):904-27
pubmed: 25376097
Antimicrob Agents Chemother. 2006 Jan;50(1):43-8
pubmed: 16377665
J Med Chem. 2016 Dec 22;59(24):11161-11170
pubmed: 27936709
J Med Chem. 2017 Jun 8;60(11):4573-4576
pubmed: 28453272
Antimicrob Agents Chemother. 2013 Sep;57(9):4197-207
pubmed: 23774440
Nat Rev Microbiol. 2012 Jul 16;10(8):525-37
pubmed: 22796883
PLoS Pathog. 2010 Aug 12;6(8):e1000949
pubmed: 20711357
J Med Chem. 2012 Feb 23;55(4):1662-70
pubmed: 22257165
MBio. 2013 Aug 20;4(4):null
pubmed: 23963183
ChemMedChem. 2016 Jan 5;11(1):15-21
pubmed: 26603496
EMBO Rep. 2015 Nov;16(11):1482-500
pubmed: 26474900
Antimicrob Agents Chemother. 2015 Dec;59(12):7743-52
pubmed: 26438502
Diagn Microbiol Infect Dis. 2013 Feb;75(2):115-20
pubmed: 23290507
ACS Infect Dis. 2018 Jul 13;4(7):1041-1047
pubmed: 29771109
Proc Natl Acad Sci U S A. 2011 Mar 15;108(11):4400-5
pubmed: 21300861
ChemMedChem. 2015 Jan;10(1):47-51
pubmed: 25314098
Biometals. 2009 Feb;22(1):61-75
pubmed: 19130268
Toxicol Lett. 1995 Dec;82-83:969-74
pubmed: 8597169
J Med Chem. 2017 Jun 8;60(11):4577-4583
pubmed: 28287735
JAMA. 1975 Jan 6;231(1):39-41
pubmed: 1243565
Antimicrob Agents Chemother. 2016 Nov 21;60(12):7396-7401
pubmed: 27736756
Microbiology. 2016 Feb;162(2):191-205
pubmed: 26643057
Cold Spring Harb Perspect Med. 2016 Jul 01;6(7):
pubmed: 27235477
J Biol Chem. 2019 Mar 8;294(10):3549-3562
pubmed: 30622135
Nat Commun. 2016 Jun 15;7:11951
pubmed: 27301800
Metallomics. 2014 Mar;6(3):408-20
pubmed: 24481292
MBio. 2014 Sep 30;5(5):e01551-14
pubmed: 25271285
Annu Rev Genet. 2016 Nov 23;50:67-91
pubmed: 27617971
Proc Natl Acad Sci U S A. 2017 Nov 28;114(48):12669-12674
pubmed: 29138321
Annu Rev Biochem. 2014;83:99-128
pubmed: 24580642
Proc Natl Acad Sci U S A. 2013 Nov 5;110(45):18244-9
pubmed: 24145449
Nat Rev Microbiol. 2004 Dec;2(12):946-53
pubmed: 15550940
Annu Rev Microbiol. 2000;54:881-941
pubmed: 11018148
ACS Med Chem Lett. 2015 Oct 02;6(11):1145-9
pubmed: 26617969
Nat Chem Biol. 2016 Sep;12(9):680-5
pubmed: 27376690
Future Med Chem. 2012 Mar;4(3):297-313
pubmed: 22393938
Nature. 2004 Aug 19;430(7002):900-4
pubmed: 15318224
ChemMedChem. 2011 Mar 7;6(3):415-9
pubmed: 21360816
Org Lett. 2014 Nov 7;16(21):5776-9
pubmed: 25331549