Lathyrus sativus diamine oxidase counteracts histamine-induced cell proliferation, migration and pro-angiogenic mediators release in human colon adenocarcinoma cell line Caco-2.

Amine Oxidase (Copper-Containing) / pharmacology Caco-2 Cells Cell Movement / drug effects Cell Proliferation / drug effects Colonic Neoplasms / blood supply Histamine Humans Lathyrus / enzymology Neovascularization, Pathologic / drug therapy
Caco-2 LSAO VEGF cell proliferation histamine occludin

Journal

Phytotherapy research : PTR
ISSN: 1099-1573
Titre abrégé: Phytother Res
Pays: England
ID NLM: 8904486

Informations de publication

Date de publication:
Jul 2019
Historique:
received: 03 02 2019
revised: 08 04 2019
accepted: 09 04 2019
pubmed: 30 5 2019
medline: 29 10 2019
entrez: 30 5 2019
Statut: ppublish

Résumé

Because histamine is a modulator of cancer cell proliferation and invasiveness, this study aimed at investigating the effect of Lathyrus sativus-derived diamine oxidase (LSAO) and its mechanism of action on Caco-2 cell line, considering that LSAO catalizes the oxidative deamination of histamine to the corresponding aldehyde, NH

Identifiants

DOI: 10.1002/ptr.6378 PMID: 31140641
pubmed: 31140641
doi: 10.1002/ptr.6378
doi:

Substances chimiques

Histamine 820484N8I3
Amine Oxidase (Copper-Containing) EC 1.4.3.21

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1878-1887

Subventions

Organisme : Regione Lazio
ID : FILAS-RU-2014-1020

Informations de copyright

© 2019 John Wiley & Sons, Ltd.

Auteurs

Paola Pietrangeli (P)

Department of Biochemical Sciences, "A. Rossi Fanelli"- Sapienza University of Rome, Rome, Italy.

Luisa Seguella (L)

Department of Physiology and Pharmacology, "V.Erspamer"- Sapienza University of Rome, Rome, Italy.

Giuseppe Annunziata (G)

Department of Pharmacy, Faculty of Pharmacy, University Federico II, Naples, Italy.
ORCID: 0000-0002-1922-662X

Fabrizio Casano (F)

Department of Physiology and Pharmacology, "V.Erspamer"- Sapienza University of Rome, Rome, Italy.

Riccardo Capuano (R)

Department of Physiology and Pharmacology, "V.Erspamer"- Sapienza University of Rome, Rome, Italy.

Mirella Pesce (M)

Department of Physiology and Pharmacology, "V.Erspamer"- Sapienza University of Rome, Rome, Italy.

Barbara De Conno (B)

Department of Clinical Medicine and Surgery, section of Gastroenterology, University Federico II, Naples, Italy.

Stefano Gigli (S)

Department of Physiology and Pharmacology, "V.Erspamer"- Sapienza University of Rome, Rome, Italy.

Giovanni Sarnelli (G)

Department of Clinical Medicine and Surgery, section of Gastroenterology, University Federico II, Naples, Italy.

Marcella Pesce (M)

Department of Clinical Medicine and Surgery, section of Gastroenterology, University Federico II, Naples, Italy.

Mircea Alexandru Mateescu (MA)

Department of Chemistry and Centre CERMO-FC, Université du Québec à Montreal, Montreal (Québec), Canada.

Giuseppe Esposito (G)

Department of Physiology and Pharmacology, "V.Erspamer"- Sapienza University of Rome, Rome, Italy.

Lucia Marcocci (L)

Department of Biochemical Sciences, "A. Rossi Fanelli"- Sapienza University of Rome, Rome, Italy.

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Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxidoreductases acting on CH-NH2 group donors › Amine oxidase (copper-containing) › Lathyrus sativus diamine oxidase counteracts...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules Caco-2 › Lathyrus sativus diamine oxidase counteracts...
questionsmedicales.fr › Phénomènes physiologiques › Mouvement cellulaire › Lathyrus sativus diamine oxidase counteracts...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Lathyrus sativus diamine oxidase counteracts...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Tumeurs de l'intestin › Tumeurs du côlon › Lathyrus sativus diamine oxidase counteracts...
questionsmedicales.fr › Facteurs biologiques › Médiateurs de l'inflammation › Autacoïdes › Histamine › Lathyrus sativus diamine oxidase counteracts...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Lathyrus sativus diamine oxidase counteracts...
questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Fabaceae › Lathyrus › Lathyrus sativus diamine oxidase counteracts...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Métaplasie › Néovascularisation pathologique › Lathyrus sativus diamine oxidase counteracts...