Methadone enhances the effectiveness of 5-aminolevulinic acid-based photodynamic therapy for squamous cell carcinoma and glioblastoma in vitro.
5-aminolevulinic acid-based photodynamic therapy (ALA-PDT)
apoptosis
cell cycle phase
glioblastoma
methadone
squamous cell carcinoma (SCC)
Journal
Journal of biophotonics
ISSN: 1864-0648
Titre abrégé: J Biophotonics
Pays: Germany
ID NLM: 101318567
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
16
12
2018
revised:
11
05
2019
accepted:
27
05
2019
pubmed:
30
5
2019
medline:
10
10
2020
entrez:
30
5
2019
Statut:
ppublish
Résumé
Although having shown promising clinical outcomes, the effectiveness of 5-aminolevulinic acid-based photodynamic therapy (ALA-PDT) for squamous cell carcinoma (SCC) and glioblastoma remains to be improved. The analgesic drug methadone is able to sensitize various tumors to chemotherapy. In this in vitro study, the influence of methadone to the effectiveness of ALA-PDT for SCC (FADU) and glioblastoma (A172) was investigated on the protoporphyrin IX (PpIX) fluorescence, survival rates, apoptosis, and cell cycle phase, each with or without the presence of methadone. The production of PpIX was increased by methadone in FADU cells while it was decreased in A172 cells. The survival rates of both cell lines treated by ALA-PDT were significantly reduced by the combination with methadone (P < .05). Methadone also significantly increased the percentage of apoptotic cells and improved the effect of ALA-PDT on the cell cycle phase arrest in the G0/G1 phase (P < .05). This study demonstrates the potential of methadone to influence the cytotoxic effect of ALA-PDT for both SCC and glioblastoma cell lines.
Identifiants
pubmed: 31140754
doi: 10.1002/jbio.201800468
doi:
Substances chimiques
Photosensitizing Agents
0
Protoporphyrins
0
Aminolevulinic Acid
88755TAZ87
protoporphyrin IX
C2K325S808
Methadone
UC6VBE7V1Z
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e201800468Subventions
Organisme : China Scholarship Council
Pays : International
Organisme : National Natural Science Foundation of China
ID : 81601601
Pays : International
Informations de copyright
© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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