Natural Antioxidant Anthocyanins-A Hidden Therapeutic Candidate in Metabolic Disorders with Major Focus in Neurodegeneration.
Animals
Anthocyanins
/ adverse effects
Antioxidants
/ adverse effects
Brain
/ drug effects
Humans
Inflammation Mediators
/ metabolism
Metabolic Syndrome
/ drug therapy
Nerve Degeneration
Neurodegenerative Diseases
/ drug therapy
Neuroprotective Agents
/ adverse effects
Oxidative Stress
/ drug effects
Reactive Oxygen Species
/ metabolism
Signal Transduction
Alzheimer’s disease
Parkinson’s disease
anthocyanins
metabolic syndrome
neuroprotection
oxidative Stress
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
28 May 2019
28 May 2019
Historique:
received:
07
05
2019
revised:
23
05
2019
accepted:
24
05
2019
entrez:
31
5
2019
pubmed:
31
5
2019
medline:
31
12
2019
Statut:
epublish
Résumé
All over the world, metabolic syndrome constitutes severe health problems. Multiple factors have been reported in the pathogenesis of metabolic syndrome. Metabolic disorders result in reactive oxygen species (ROS) induced oxidative stress, playing a vital role in the development and pathogenesis of major health issues, including neurological disorders Alzheimer's disease (AD) Parkinson's disease (PD). Considerable increasing evidence indicates the substantial contribution of ROS-induced oxidative stress in neurodegenerative diseases. An imbalanced metabolism results in a defective antioxidant defense system, free radicals causing inflammation, cellular apoptosis, and tissue damage. Due to the annual increase in financial and social burdens, in addition to the adverse effects associated with available synthetic agents, treatment diversion from synthetic to natural approaches has occurred. Antioxidants are now being considered as convincing therapeutic agents against various neurodegenerative disorders. Therefore, medicinal herbs and fruits currently receive substantially more attention as commercial sources of antioxidants. In this review, we argue that ROS-targeted therapeutic interventions with naturally occurring antioxidant flavonoid, anthocyanin, and anthocyanin-loaded nanoparticles might be the ultimate treatment against devastating illnesses. Furthermore, we elucidate the hidden potential of the neuroprotective role of anthocyanins and anthocyanin-loaded nanoparticles in AD and PD neuropathies, which lack sufficient attention compared with other polyphenols, despite their strong antioxidant potential. Moreover, we address the need for future research studies of native anthocyanins and nano-based-anthocyanins, which will be helpful in developing anthocyanin treatments as therapeutic mitochondrial antioxidant drug-like regimens to delay or prevent the progression of neurodegenerative diseases, such as AD and PD.
Identifiants
pubmed: 31141884
pii: nu11061195
doi: 10.3390/nu11061195
pmc: PMC6628002
pii:
doi:
Substances chimiques
Anthocyanins
0
Antioxidants
0
Inflammation Mediators
0
Neuroprotective Agents
0
Reactive Oxygen Species
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors declared no competing financial interests.
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