Histocompatibility locus antigens regions contribute to the ethnicity bias of Epstein-Barr virus-associated nasopharyngeal carcinoma in higher-incidence populations.
Bias
Epstein-Barr Virus Infections
/ epidemiology
Ethnicity
Gene Frequency
Genetic Predisposition to Disease
Genotype
HLA Antigens
/ genetics
Herpesvirus 4, Human
/ physiology
Histocompatibility
/ genetics
Humans
Immunity
/ genetics
India
/ epidemiology
Nasopharyngeal Carcinoma
/ epidemiology
Nasopharyngeal Neoplasms
/ epidemiology
Polymorphism, Genetic
Epstein-Barr virus
histocompatibility locus antigens
mongoloid races
nasopharyngeal carcinoma
polymorphism
Journal
Scandinavian journal of immunology
ISSN: 1365-3083
Titre abrégé: Scand J Immunol
Pays: England
ID NLM: 0323767
Informations de publication
Date de publication:
Oct 2019
Oct 2019
Historique:
received:
17
01
2019
accepted:
28
05
2019
pubmed:
31
5
2019
medline:
24
9
2019
entrez:
31
5
2019
Statut:
ppublish
Résumé
Nasopharyngeal carcinoma (NPC) is one the most confusing and rare malignancy in most part of the world with significantly high occurrence in some populations of Southeast Asia, North Africa and Alaska. Apart from the dietary and environmental factors, NPC is well-associated with Epstein-Barr virus (EBV) infection in these ethnic groups. However, the internal molecular mechanism(s) for such association in specific populations is not known till date. Polymorphisms in the genes of histocompatibility locus antigens (HLA) are reported in NPC, but association of any particular polymorphism with ethnicity is not established yet. Here, we report a set of HLA polymorphisms in EBV-infected NPC samples from Northeast Indian population. These polymorphisms might play an important role for the lack of proper immune function against EBV infection and thus, eventually, for NPC generation in endemic populations like those of Northeast India.
Substances chimiques
HLA Antigens
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e12796Subventions
Organisme : Department of Biotechnology , Ministry of Science and Technology
Informations de copyright
© 2019 The Foundation for the Scandinavian Journal of Immunology.
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