CTLA-4 Protects against Angiotensin II-Induced Abdominal Aortic Aneurysm Formation in Mice.
Angiotensin II
/ toxicity
Animals
Aorta, Abdominal
/ drug effects
Aortic Aneurysm, Abdominal
/ chemically induced
Aortic Rupture
/ chemically induced
Atherosclerosis
/ complications
CTLA-4 Antigen
/ genetics
Diet, Atherogenic
/ adverse effects
Disease Models, Animal
Humans
Male
Mice
Mice, Knockout, ApoE
Severity of Illness Index
T-Lymphocytes
/ immunology
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
30 05 2019
30 05 2019
Historique:
received:
01
03
2019
accepted:
17
05
2019
entrez:
1
6
2019
pubmed:
31
5
2019
medline:
24
10
2020
Statut:
epublish
Résumé
Vascular inflammation via T-cell-mediated immune responses has been shown to be critically involved in the pathogenesis of abdominal aortic aneurysm (AAA). T-cell coinhibitory molecule cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) is known to act as a potent negative regulator of immune responses. However, the role of this molecule in the development of AAA remains completely unknown. We determined the effects of CTLA-4 overexpression on experimental AAA. We continuously infused CTLA-4 transgenic (CTLA-4-Tg)/apolipoprotein E-deficient (Apoe
Identifiants
pubmed: 31147569
doi: 10.1038/s41598-019-44523-6
pii: 10.1038/s41598-019-44523-6
pmc: PMC6542846
doi:
Substances chimiques
CTLA-4 Antigen
0
Ctla4 protein, mouse
0
Angiotensin II
11128-99-7
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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