Role of magnetic resonance spectroscopy in cerebral glutathione quantification for youth mental health: A systematic review.
glutathione
magnetic resonance spectroscopy
youth mental health
Journal
Early intervention in psychiatry
ISSN: 1751-7893
Titre abrégé: Early Interv Psychiatry
Pays: Australia
ID NLM: 101320027
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
04
09
2018
revised:
27
02
2019
accepted:
14
04
2019
pubmed:
31
5
2019
medline:
12
1
2021
entrez:
1
6
2019
Statut:
ppublish
Résumé
Oxidative stress is strongly implicated in many psychiatric disorders, which has resulted in the development of new interventions to attempt to perturb this pathology. A great deal of attention has been paid to glutathione, which is the brain's dominant antioxidant and plays a fundamental role in removing free radicals and other reactive oxygen species. Measurement of glutathione concentration in the brain in vivo can provide information on redox status and potential for oxidative stress to develop. Glutathione might also represent a marker to assess treatment response. This paper systematically reviews studies that assess glutathione concentration (measured using magnetic resonance spectroscopy) in various mental health conditions. There is limited evidence showing altered brain glutathione concentration in mental disorders; the best evidence suggests glutathione is decreased in depression, but is not altered in bipolar disorder. The review then outlines the various methodological options for acquiring glutathione data using spectroscopy. Analysis of the minimum effect size measurable in existing studies indicates that increased number of participants is required to measure subtle but possibly important differences and move the field forward.
Identifiants
pubmed: 31148383
doi: 10.1111/eip.12833
pmc: PMC7065077
doi:
Substances chimiques
Glutathione
GAN16C9B8O
Types de publication
Journal Article
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
147-162Informations de copyright
© 2019 The Authors Early Intervention in Psychiatry Published by John Wiley & Sons Australia, Ltd.
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