Autoimmune hepatitis and IgG4-related disease.
Autoimmune hepatitis
IgG4
IgG4-associated autoimmune hepatitis
IgG4-related disease
Journal
World journal of gastroenterology
ISSN: 2219-2840
Titre abrégé: World J Gastroenterol
Pays: United States
ID NLM: 100883448
Informations de publication
Date de publication:
21 May 2019
21 May 2019
Historique:
received:
08
03
2019
revised:
13
04
2019
accepted:
19
04
2019
entrez:
1
6
2019
pubmed:
1
6
2019
medline:
4
12
2019
Statut:
ppublish
Résumé
IgG4-related disease (IgG4-RD) is a chronic-fibroinflammatory disorder affecting a wide range of organs. Elevation of serum IgG4 concentrations and abundant infiltration of IgG4-expressing plasma cells are key diagnostic features of this autoimmune disease. Although common organ involvement of IgG4-RD includes the salivary glands, pancreas, and bile duct, hepatic involvement is less well established. Recently, five studies identified a subtype of autoimmune hepatitis (AIH), called IgG4-associated AIH (IgG4-AIH). IgG4-AIH is diagnosed based on significant accumulation of IgG4-expressing plasmacytes in the liver in patients who met the diagnostic criteria for classical AIH. Although four of the five reports regarded IgG4-AIH based on hepatic accumulation of IgG4-positive cells alone, one report diagnosed IgG4-AIH based on both hepatic accumulation of IgG4-positive cells and elevated serum concentrations of IgG4. IgG4-AIH diagnosed based on the latter criteria may be a hepatic manifestation of IgG4-RD whereas IgG4-AIH diagnosed based on the former criteria may be a subtype of AIH. In this review article, we summarize and discuss clinicopathological features of IgG4-AIH.
Identifiants
pubmed: 31148902
doi: 10.3748/wjg.v25.i19.2308
pmc: PMC6529891
doi:
Substances chimiques
Immunoglobulin G
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2308-2314Commentaires et corrections
Type : CommentIn
Déclaration de conflit d'intérêts
Conflict–of-interest statement: No potential conflicts of interest. No financial support.
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