Differences in immune contextures among different molecular subtypes of gastric cancer and their prognostic impact.
Aged
B7-H1 Antigen
/ genetics
Female
Forkhead Transcription Factors
/ metabolism
Humans
Lymphatic Metastasis
Lymphocytes, Tumor-Infiltrating
/ pathology
Male
Microsatellite Instability
Middle Aged
Neoplasm Invasiveness
Prognosis
Stomach Neoplasms
/ genetics
Survival Rate
Tumor Microenvironment
/ immunology
Gastric cancer
Survival
Tumor microenvironment
Tumor-infiltrating lymphocytes
Journal
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association
ISSN: 1436-3305
Titre abrégé: Gastric Cancer
Pays: Japan
ID NLM: 100886238
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
received:
12
02
2019
accepted:
15
05
2019
pubmed:
4
6
2019
medline:
15
4
2020
entrez:
2
6
2019
Statut:
ppublish
Résumé
Gastric cancers have been recently classified in accordance with their molecular characteristics, thus demonstrating the complex nature of cancers and an association with the immune contexture within the tumor microenvironment. This study aimed to investigate the correlation between the molecular subtype and immune contexture of gastric cancers. The immune contexture, including the type, density, and location of tumor-infiltrating lymphocytes (TILs), of gastric cancer patients was examined and immune subtypes were classified based on it. In particular, PD-L1 expression on tumor cells and TILs and Foxp3 High levels of visual TIL estimates and Foxp3 The molecular subtype of gastric cancers is correlated with the immune subtype, including immune contexture and PD-L1 expression, within the tumor microenvironment.
Sections du résumé
BACKGROUND
Gastric cancers have been recently classified in accordance with their molecular characteristics, thus demonstrating the complex nature of cancers and an association with the immune contexture within the tumor microenvironment. This study aimed to investigate the correlation between the molecular subtype and immune contexture of gastric cancers.
METHODS
The immune contexture, including the type, density, and location of tumor-infiltrating lymphocytes (TILs), of gastric cancer patients was examined and immune subtypes were classified based on it. In particular, PD-L1 expression on tumor cells and TILs and Foxp3
RESULTS
High levels of visual TIL estimates and Foxp3
CONCLUSION
The molecular subtype of gastric cancers is correlated with the immune subtype, including immune contexture and PD-L1 expression, within the tumor microenvironment.
Identifiants
pubmed: 31152268
doi: 10.1007/s10120-019-00974-4
pii: 10.1007/s10120-019-00974-4
doi:
Substances chimiques
B7-H1 Antigen
0
CD274 protein, human
0
FOXP3 protein, human
0
Forkhead Transcription Factors
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1164-1175Subventions
Organisme : National Research Foundation
ID : NRF-2018R1C1B6004754
Pays : International
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