The cross talk of adrenal and Leydig cell steroids in Leydig cells.
11β-hydroxysteroid dehydrogenase
Glucocorticoid
Intracellular receptor transcription factor
Leydig cells
Testosterone
Journal
The Journal of steroid biochemistry and molecular biology
ISSN: 1879-1220
Titre abrégé: J Steroid Biochem Mol Biol
Pays: England
ID NLM: 9015483
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
received:
22
01
2019
revised:
27
05
2019
accepted:
28
05
2019
pubmed:
4
6
2019
medline:
22
1
2020
entrez:
2
6
2019
Statut:
ppublish
Résumé
Glucocorticoid is secreted by adrenal cortex, which binds to intracellular glucocorticoid and mineralocorticoid receptors to regulate steroidogenesis-related gene expression and testosterone production in Leydig cells. Glucocorticoid receptor activity shows inhibitory action on Leydig cell steroidogenesis, while mineralocorticoid receptor activity shows the stimulatory action. Leydig cells contain two important glucocorticoid-metabolizing enzymes, 11β-hydroxysteroid dehydrogenase type 1 and type 2, regulating the intracellular levels of glucocorticoids by a pre-receptor mechanism. 11β-Hydroxysteroid dehydrogenase type 1 is a bidirectional enzyme, and its direction is regulated by intracellular NADP
Identifiants
pubmed: 31152782
pii: S0960-0760(19)30046-9
doi: 10.1016/j.jsbmb.2019.105386
pii:
doi:
Substances chimiques
Glucocorticoids
0
Testosterone
3XMK78S47O
11-beta-Hydroxysteroid Dehydrogenase Type 1
EC 1.1.1.146
Corticosterone
W980KJ009P
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
105386Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.