Co-administration of Magnesium Oxide Reduces the Serum Concentration of Hydrophobic Basic Drugs in Patients Treated with Antipsychotic Drugs.

Adult Aged Aged, 80 and over Antipsychotic Agents / blood Biperiden / blood Dibenzothiepins / blood Drug Interactions Drug Therapy, Combination Female Humans Hydrophobic and Hydrophilic Interactions Laxatives / pharmacology Magnesium Oxide / pharmacology Male Middle Aged Risperidone / blood Schizophrenia / blood
acidity constant anti-cholinergic action drug solubility gastric secretion schizophrenia

Journal

Biological & pharmaceutical bulletin
ISSN: 1347-5215
Titre abrégé: Biol Pharm Bull
Pays: Japan
ID NLM: 9311984

Informations de publication

Date de publication:
2019
Historique:
entrez: 4 6 2019
pubmed: 4 6 2019
medline: 26 11 2019
Statut: ppublish

Résumé

Magnesium oxide (MgO) is a widely used laxative. Because many antipsychotic drugs are lipophilic-basic-compounds, their solubility decreases with increasing pH and changes markedly as the pH of the solution approaches their pK

Identifiants

DOI: 10.1248/bpb.b18-00733 PMID: 31155577
pubmed: 31155577
doi: 10.1248/bpb.b18-00733
doi:

Substances chimiques

Antipsychotic Agents 0
Dibenzothiepins 0
Laxatives 0
Biperiden 0FRP6G56LD
Magnesium Oxide 3A3U0GI71G
Risperidone L6UH7ZF8HC
zotepine U29O83JAZW

Types de publication

Controlled Clinical Trial Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1025-1029

Auteurs

Hisahiro Yoshida (H)

Department of Drug Metabolism and Disposition, Meiji Pharmaceutical University.
Education and Research Center for Clinical Pharmacy, Division of Pharmacy Education, Kyoto Pharmaceutical University.

Minori Takahashi (M)

Department of Drug Metabolism and Disposition, Meiji Pharmaceutical University.

Misuzu Honda (M)

Department of Drug Metabolism and Disposition, Meiji Pharmaceutical University.

Hideaki Amayasu (H)

Division of Psychiatry, Heartful Kawasaki Hospital.

Masazumi Ando (M)

Department of Drug Metabolism and Disposition, Meiji Pharmaceutical University.
Department of Pharmacy, Heartful Kawasaki Hospital.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Co-administration of Magnesium Oxide Reduces...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Co-administration of Magnesium Oxide Reduces...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Sujet âgé de 80 ans ou plus › Co-administration of Magnesium Oxide Reduces...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Psychoanaleptiques › Tranquillisants › Neuroleptiques › Co-administration of Magnesium Oxide Reduces...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques, cycle ponté › Composés hétérocycliques bicycliques › Composés azabicycliques › Bipéridène › Co-administration of Magnesium Oxide Reduces...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérocycliques 3 noyaux › Dibenzothiépines › Co-administration of Magnesium Oxide Reduces...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Interactions médicamenteuses › Co-administration of Magnesium Oxide Reduces...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Association de médicaments › Co-administration of Magnesium Oxide Reduces...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Co-administration of Magnesium Oxide Reduces...
questionsmedicales.fr › Phénomènes chimiques › Interactions hydrophobes et hydrophiles › Co-administration of Magnesium Oxide Reduces...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents gastro-intestinaux › Laxatifs › Co-administration of Magnesium Oxide Reduces...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Oxydes › Oxyde de magnésium › Co-administration of Magnesium Oxide Reduces...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Co-administration of Magnesium Oxide Reduces...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyrimidines › Pyrimidinones › Rispéridone › Co-administration of Magnesium Oxide Reduces...
questionsmedicales.fr › Troubles mentaux › Schizophrénie et troubles avec traits psychotiques › Schizophrénie › Co-administration of Magnesium Oxide Reduces...