Discovery, Characterisation, Engineering and Applications of Ene Reductases for Industrial Biocatalysis.
Ene-reductases
Old Yellow Enzymes
asymmetric alkene reduction
biocatalysis
synthetic biology
Journal
ACS catalysis
ISSN: 2155-5435
Titre abrégé: ACS Catal
Pays: United States
ID NLM: 101562209
Informations de publication
Date de publication:
15 May 2019
15 May 2019
Historique:
entrez:
4
6
2019
pubmed:
4
6
2019
medline:
4
6
2019
Statut:
ppublish
Résumé
Recent studies of multiple enzyme families collectively referred to as ene-reductases (ERs) have highlighted potential industrial application of these biocatalysts in the production of fine and speciality chemicals. Processes have been developed whereby ERs contribute to synthetic routes as isolated enzymes, components of multi-enzyme cascades, and more recently in metabolic engineering and synthetic biology programmes using microbial cell factories to support chemicals production. The discovery of ERs from previously untapped sources and the expansion of directed evolution screening programmes, coupled to deeper mechanistic understanding of ER reactions, have driven their use in natural product and chemicals synthesis. Here we review developments, challenges and opportunities for the use of ERs in fine and speciality chemicals manufacture. The ER research field is rapidly expanding and the focus of this review is on developments that have emerged predominantly over the last 4 years.
Identifiants
pubmed: 31157123
doi: 10.1021/acscatal.8b00624
pmc: PMC6542678
mid: EMS82894
doi:
Types de publication
Journal Article
Langues
eng
Pagination
3532-3549Subventions
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/K00199X/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/M017702/1
Pays : United Kingdom
Déclaration de conflit d'intérêts
Notes The authors declare no competing financial interest.
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