Nigel S Scrutton

Affiliations

Manchester Institute of Biotechnology, The University of Manchester, UK.
Department of Chemistry, Faculty of Science and Engineering, School of Natural Sciences, The University of Manchester, UK.

Publications (90)

Dual role of the active site 'lid' regions of protochlorophyllide oxidoreductase in photocatalysis and plant development.

The FEBS journal

Avec: Shaowei Zhang , Alan R F Godwin , Aoife Taylor , Samantha J O Hardman , Thomas A Jowitt , Linus O Johannissen , Sam Hay , Clair Baldock , Derren J Heyes , Nigel S Scrutton

Unexpected Roles of a Tether Harboring a Tyrosine Gatekeeper Residue in Modular Nitrite Reductase Catalysis.

ACS catalysis

Avec: Tobias M Hedison , Rajesh T Shenoy , Andreea I Iorgu , Derren J Heyes , Karl Fisher , Gareth S A Wright , Sam Hay , Robert R Eady , Svetlana V Antonyuk , S Samar Hasnain , Nigel S Scrutton

Selective cellular imaging with lanthanide-based upconversion nanoparticles.

Journal of biophotonics

Avec: Padmaja P Nampi , Alexander Vakurov , Lewis E Mackenzie , Nigel S Scrutton , Paul A Millner , Gin Jose , Sikha Saha

Synthetic biology for fibres, adhesives and active camouflage materials in protection and aerospace.

MRS communications

Avec: Aled D Roberts , William Finnigan , Emmanuel Wolde-Michael , Paul Kelly , Jonny J Blaker , Sam Hay , Rainer Breitling , Eriko Takano , Nigel S Scrutton

Author Correction: Building a global alliance of biofoundries.

Nature communications

Avec: Nathan Hillson , Mark Caddick , Yizhi Cai , Jose A Carrasco , Matthew Wook Chang , Natalie C Curach , David J Bell , Rosalind Le Feuvre , Douglas C Friedman , Xiongfei Fu , Nicholas D Gold , Markus J Herrgård , Maciej B Holowko , James R Johnson , Richard A Johnson , Jay D Keasling , Richard I Kitney , Akihiko Kondo , Chenli Liu , Vincent J J Martin , Filippo Menolascina , Chiaki Ogino , Nicola J Patron , Marilene Pavan , Chueh Loo Poh , Isak S Pretorius , Susan J Rosser , Nigel S Scrutton , Marko Storch , Hille Tekotte , Evelyn Travnik , Claudia E Vickers , Wen Shan Yew , Yingjin Yuan , Huimin Zhao , Paul S Freemont

SelProm: A Queryable and Predictive Expression Vector Selection Tool for

ACS synthetic biology

Avec: Adrian J Jervis , Pablo Carbonell , Sandra Taylor , Rehana Sung , Mark S Dunstan , Christopher J Robinson , Rainer Breitling , Eriko Takano , Nigel S Scrutton

Isotopically labeled flavoenzymes and their uses in probing reaction mechanisms.

Methods in enzymology

Avec: Andreea I Iorgu , Matthew J Cliff , Jonathan P Waltho , Nigel S Scrutton , Sam Hay

Selectivity through discriminatory induced fit enables switching of NAD(P)H coenzyme specificity in Old Yellow Enzyme ene-reductases.

The FEBS journal

Avec: Andreea I Iorgu , Tobias M Hedison , Sam Hay , Nigel S Scrutton

Structural basis for enzymatic photocatalysis in chlorophyll biosynthesis.

Nature

Avec: Shaowei Zhang , Derren J Heyes , Lingling Feng , Wenli Sun , Linus O Johannissen , Huanting Liu , Colin W Levy , Xuemei Li , Ji Yang , Xiaolan Yu , Min Lin , Samantha J O Hardman , Robin Hoeven , Michiyo Sakuma , Sam Hay , David Leys , Zihe Rao , Aiwu Zhou , Qi Cheng , Nigel S Scrutton

Highly multiplexed, fast and accurate nanopore sequencing for verification of synthetic DNA constructs and sequence libraries.

Synthetic biology (Oxford, England)

Avec: Andrew Currin , Neil Swainston , Mark S Dunstan , Adrian J Jervis , Paul Mulherin , Christopher J Robinson , Sandra Taylor , Pablo Carbonell , Katherine A Hollywood , Cunyu Yan , Eriko Takano , Nigel S Scrutton , Rainer Breitling

Design and fabrication of recombinant reflectin-based multilayer reflectors: bio-design engineering and photoisomerism induced wavelength modulation.

Scientific reports

Avec: Emmanuel Wolde-Michael , Aled D Roberts , Derren J Heyes , Ahu G Dumanli , Jonny J Blaker , Eriko Takano , Nigel S Scrutton

How a 10-

ACS catalysis

Avec: Joshua N Whitehead , Nicole G H Leferink , Gajendar Komati Reddy , Colin W Levy , Sam Hay , Eriko Takano , Nigel S Scrutton

Bioproduction of Linalool From Paper Mill Waste.

Frontiers in bioengineering and biotechnology

Avec: Mauro A Rinaldi , Shirley Tait , Helen S Toogood , Nigel S Scrutton

Single crystal spectroscopy and multiple structures from one crystal (MSOX) define catalysis in copper nitrite reductases.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Samuel L Rose , Seiki Baba , Hideo Okumura , Svetlana V Antonyuk , Daisuke Sasaki , Tobias M Hedison , Muralidharan Shanmugam , Derren J Heyes , Nigel S Scrutton , Takashi Kumasaka , Takehiko Tosha , Robert R Eady , Masaki Yamamoto , S Samar Hasnain

Unravelling the complexity of enzyme catalysis.

The FEBS journal

Avec: Nigel S Scrutton

Mutation in a chlorophyll-binding motif of Brassica ferrochelatase enhances both heme and chlorophyll biosynthesis.

Cell reports

Avec: Mengyang Liu , Wei Ma , Xiangjie Su , Xiaomeng Zhang , Yin Lu , Shaowei Zhang , Jinghui Yan , Daling Feng , Lisong Ma , Aoife Taylor , Yunjia Ge , Qi Cheng , Kedong Xu , Yanhua Wang , Na Li , Aixia Gu , Ju Zhang , Shuangxia Luo , Shuxin Xuan , Xueping Chen , Nigel S Scrutton , Chengwei Li , Jianjun Zhao , Shuxing Shen

Photocobilins integrate B

Nature communications

Avec: Shaowei Zhang , Laura N Jeffreys , Harshwardhan Poddar , Yuqi Yu , Chuanyang Liu , Kaylee Patel , Linus O Johannissen , Lingyun Zhu , Matthew J Cliff , Cunyu Yan , Giorgio Schirò , Martin Weik , Michiyo Sakuma , Colin W Levy , David Leys , Derren J Heyes , Nigel S Scrutton

An automated pipeline for the screening of diverse monoterpene synthase libraries.

Scientific reports

Avec: Nicole G H Leferink , Mark S Dunstan , Katherine A Hollywood , Neil Swainston , Andrew Currin , Adrian J Jervis , Eriko Takano , Nigel S Scrutton

Machine Learning of Designed Translational Control Allows Predictive Pathway Optimization in Escherichia coli.

ACS synthetic biology

Avec: Adrian J Jervis , Pablo Carbonell , Maria Vinaixa , Mark S Dunstan , Katherine A Hollywood , Christopher J Robinson , Nicholas J W Rattray , Cunyu Yan , Neil Swainston , Andrew Currin , Rehana Sung , Helen Toogood , Sandra Taylor , Jean-Loup Faulon , Rainer Breitling , Eriko Takano , Nigel S Scrutton

Protein Conformational Change Is Essential for Reductive Activation of Lytic Polysaccharide Monooxygenase by Cellobiose Dehydrogenase.

ACS catalysis

Avec: Erik Breslmayr , Christophe V F P Laurent , Stefan Scheiblbrandner , Anita Jerkovic , Derren J Heyes , Chris Oostenbrink , Roland Ludwig , Tobias M Hedison , Nigel S Scrutton , Daniel Kracher

Renewable and tuneable bio-LPG blends derived from amino acids.

Biotechnology for biofuels

Avec: Mohamed Amer , Robin Hoeven , Paul Kelly , Matthew Faulkner , Michael H Smith , Helen S Toogood , Nigel S Scrutton

The effect of terminal globular domains on the response of recombinant mini-spidroins to fiber spinning triggers.

Scientific reports

Avec: William Finnigan , Aled D Roberts , Cosimo Ligorio , Nigel S Scrutton , Rainer Breitling , Jonny J Blaker , Eriko Takano

Catalytic Mechanism of Aromatic Nitration by Cytochrome P450 TxtE: Involvement of a Ferric-Peroxynitrite Intermediate.

Journal of the American Chemical Society

Avec: Savvas Louka , Sarah M Barry , Derren J Heyes , M Qadri E Mubarak , Hafiz Saqib Ali , Lona M Alkhalaf , Andrew W Munro , Nigel S Scrutton , Gregory L Challis , Sam P de Visser

Photocycle of Cyanobacteriochrome TePixJ.

Biochemistry

Avec: Samantha J O Hardman , Derren J Heyes , Igor V Sazanovich , Nigel S Scrutton

Techno-economic assessment of microbial limonene production.

Bioresource technology

Avec: Chenhao Sun , Constantinos Theodoropoulos , Nigel S Scrutton

Exploiting Single Domain Antibodies as Regulatory Parts to Modulate Monoterpenoid Production in

ACS synthetic biology

Avec: Jonathan Wilkes , Anthony Scott-Tucker , Mike Wright , Tom Crabbe , Nigel S Scrutton

Predictive Engineering of Class I Terpene Synthases Using Experimental and Computational Approaches.

Chembiochem : a European journal of chemical biology

Avec: Nicole G H Leferink , Nigel S Scrutton

Advantages of brain penetrating inhibitors of kynurenine-3-monooxygenase for treatment of neurodegenerative diseases.

Archives of biochemistry and biophysics

Avec: Shaowei Zhang , Mary E W Collier , Derren J Heyes , Flaviano Giorgini , Nigel S Scrutton

Prototyping of microbial chassis for the biomanufacturing of high-value chemical targets.

Biochemical Society transactions

Avec: Christopher J Robinson , Jonathan Tellechea-Luzardo , Pablo Carbonell , Adrian J Jervis , Cunyu Yan , Katherine A Hollywood , Mark S Dunstan , Andrew Currin , Eriko Takano , Nigel S Scrutton

A Biological Route to Conjugated Alkenes: Microbial Production of Hepta-1,3,5-triene.

ACS synthetic biology

Avec: Hanan L Messiha , Karl A P Payne , Nigel S Scrutton , David Leys

PHA is not just a bioplastic!

Biotechnology advances

Avec: Helen Park , Hongtao He , Xu Yan , Xu Liu , Nigel S Scrutton , Guo-Qiang Chen

Solution-State Inter-Copper Distribution of Redox Partner-Linked Copper Nitrite Reductases: A Pulsed Electron-Electron Double Resonance Spectroscopy Study.

The journal of physical chemistry letters

Avec: Tobias M Hedison , Andreea I Iorgu , Donato Calabrese , Derren J Heyes , Muralidharan Shanmugam , Nigel S Scrutton

Co-production of biofuel, bioplastics and biochemicals during extended fermentation of Halomonas bluephagenesis.

Microbial biotechnology

Avec: Helen Park , Helen S Toogood , Guo-Qiang Chen , Nigel S Scrutton

Biosynthesis of cannabigerol and cannabigerolic acid: the gateways to further cannabinoid production.

Synthetic biology (Oxford, England)

Avec: Lewis J Kearsey , Cunyu Yan , Nicole Prandi , Helen S Toogood , Eriko Takano , Nigel S Scrutton

Mapping the Initial Stages of a Protective Pathway that Enhances Catalytic Turnover by a Lytic Polysaccharide Monooxygenase.

Journal of the American Chemical Society

Avec: Jingming Zhao , Ying Zhuo , Daniel E Diaz , Muralidharan Shanmugam , Abbey J Telfer , Peter J Lindley , Daniel Kracher , Takahiro Hayashi , Lisa S Seibt , Florence J Hardy , Oliver Manners , Tobias M Hedison , Katherine A Hollywood , Reynard Spiess , Kathleen M Cain , Sofia Diaz-Moreno , Nigel S Scrutton , Morten Tovborg , Paul H Walton , Derren J Heyes , Anthony P Green

Non-covalent protein-based adhesives for transparent substrates-bovine serum albumin vs. recombinant spider silk.

Materials today. Bio

Avec: A D Roberts , W Finnigan , P P Kelly , M Faulkner , R Breitling , E Takano , N S Scrutton , J J Blaker , S Hay

Structure of the Cannabis sativa olivetol-producing enzyme reveals cyclization plasticity in type III polyketide synthases.

The FEBS journal

Avec: Lewis J Kearsey , Nicole Prandi , Vijaykumar Karuppiah , Cunyu Yan , David Leys , Helen Toogood , Eriko Takano , Nigel S Scrutton

Taming the Reactivity of Monoterpene Synthases To Guide Regioselective Product Hydroxylation.

Chembiochem : a European journal of chemical biology

Avec: Nicole G H Leferink , Kara E Ranaghan , Jaime Battye , Linus O Johannissen , Sam Hay , Marc W van der Kamp , Adrian J Mulholland , Nigel S Scrutton

Light-induced structural changes in a full-length cyanobacterial phytochrome probed by time-resolved X-ray scattering.

Communications biology

Avec: Derren J Heyes , Samantha J O Hardman , Martin N Pedersen , Joyce Woodhouse , Eugenio De La Mora , Michael Wulff , Martin Weik , Marco Cammarata , Nigel S Scrutton , Giorgio Schirò

Observation of the Δg mechanism resulting from the ultrafast spin dynamics that follow the photolysis of coenzyme B

The Journal of chemical physics

Avec: Joanna A Hughes , Samantha J O Hardman , Nigel S Scrutton , Darren M Graham , Jonathan R Woodward , Alex R Jones

In conversation with Nigel Scrutton.

The FEBS journal

Avec: Paraminder Dhillon , Nigel S Scrutton

Streamlining Natural Products Biomanufacturing With Omics and Machine Learning Driven Microbial Engineering.

Frontiers in bioengineering and biotechnology

Avec: Ahmad Bazli Ramzi , Syarul Nataqain Baharum , Hamidun Bunawan , Nigel S Scrutton

Promoter engineering for microbial bio-alkane gas production.

Synthetic biology (Oxford, England)

Avec: Duangthip Trisrivirat , John M X Hughes , Robin Hoeven , Matthew Faulkner , Helen Toogood , Pimchai Chaiyen , Nigel S Scrutton

A guide to time-resolved structural analysis of light-activated proteins.

The FEBS journal

Avec: Harshwardhan Poddar , Derren J Heyes , Giorgio Schirò , Martin Weik , David Leys , Nigel S Scrutton

Photocatalysis as the 'master switch' of photomorphogenesis in early plant development.

Nature plants

Avec: Derren J Heyes , Shaowei Zhang , Aoife Taylor , Linus O Johannissen , Samantha J O Hardman , Sam Hay , Nigel S Scrutton

Inflammation control and improvement of cognitive function in COVID-19 infections: is there a role for kynurenine 3-monooxygenase inhibition?

Drug discovery today

Avec: Mary Ew Collier , Shaowei Zhang , Nigel S Scrutton , Flaviano Giorgini

Engineering nature for gaseous hydrocarbon production.

Microbial cell factories

Avec: Mohamed Amer , Helen Toogood , Nigel S Scrutton

Blood, sweat, and tears: extraterrestrial regolith biocomposites with

Materials today. Bio

Avec: A D Roberts , D R Whittall , R Breitling , E Takano , J J Blaker , S Hay , N S Scrutton

Mechanistic implications of the ternary complex structural models for the photoenzyme protochlorophyllide oxidoreductase.

The FEBS journal

Avec: Aoife Taylor , Shaowei Zhang , Linus O Johannissen , Michiyo Sakuma , Robert S Phillips , Anthony P Green , Sam Hay , Derren J Heyes , Nigel S Scrutton

Chemoautotrophic production of gaseous hydrocarbons, bioplastics and osmolytes by a novel Halomonas species.

Biotechnology for biofuels and bioproducts

Avec: Matthew Faulkner , Robin Hoeven , Paul P Kelly , Yaqi Sun , Helen Park , Lu-Ning Liu , Helen S Toogood , Nigel S Scrutton

Baseline proteomics characterisation of the emerging host biomanufacturing organism Halomonas bluephagenesis.

Scientific data

Avec: Matthew Russell , Andrew Currin , William Rowe , Guo-Qiang Chen , Perdita Barran , Nigel S Scrutton

Catalysis by Nature's photoenzymes.

Current opinion in structural biology

Avec: Aoife Taylor , Derren J Heyes , Nigel S Scrutton

Photoinduced Electron Transfer from a 1,4,5,6-Tetrahydro Nicotinamide Adenine Dinucleotide (Phosphate) Analogue to Oxidized Flavin in an Ene-Reductase Flavoenzyme.

The journal of physical chemistry letters

Avec: Magnus Speirs , Samantha J O Hardman , Andreea I Iorgu , Linus O Johannissen , Derren J Heyes , Nigel S Scrutton , Igor V Sazanovich , Sam Hay

Mechanism of Action of Flavin-Dependent Halogenases.

ACS catalysis

Avec: Rhys D Barker , Yuqi Yu , Leonardo De Maria , Linus O Johannissen , Nigel S Scrutton

A Long-Term Growth Stable Halomonas sp. Deleted with Multiple Transposases Guided by Its Metabolic Network Model Halo-ecGEM.

Metabolic engineering

Avec: Lizhan Zhang , Jian-Wen Ye , Gang Li , Helen Park , Hao Luo , Yina Lin , Shaowei Li , Weinan Yang , Yuying Guan , Fuqing Wu , Wuzhe Huang , Qiong Wu , Nigel S Scrutton , Jens Nielsen , Guo-Qiang Chen

Engineering

Synthetic biology (Oxford, England)

Avec: Mark S Dunstan , Christopher J Robinson , Adrian J Jervis , Cunyu Yan , Pablo Carbonell , Katherine A Hollywood , Andrew Currin , Neil Swainston , Rosalind Le Feuvre , Jason Micklefield , Jean-Loup Faulon , Rainer Breitling , Nicholas Turner , Eriko Takano , Nigel S Scrutton

Synthetic biology (Oxford, England)

Avec: Pablo Carbonell , Rosalind Le Feuvre , Eriko Takano , Nigel S Scrutton

Convergence of theory and experiment on the role of preorganization, quantum tunneling and enzyme motions into flavoenzyme-catalyzed hydride transfer.

ACS catalysis

Avec: Manuel Delgado , Stefan Görlich , James E Longbotham , Nigel S Scrutton , Sam Hay , Vicent Moliner , Iñaki Tuñón

Experiment and Simulation Reveal How Mutations in Functional Plasticity Regions Guide Plant Monoterpene Synthase Product Outcome.

ACS catalysis

Avec: Nicole G H Leferink , Kara E Ranaghan , Vijaykumar Karuppiah , Andrew Currin , Marc W van der Kamp , Adrian J Mulholland , Nigel S Scrutton

Bio-derived Production of Cinnamyl Alcohol via a Three Step Biocatalytic Cascade and Metabolic Engineering.

Green chemistry : an international journal and green chemistry resource : GC

Avec: Evaldas Klumbys , Ziga Zebec , Nicholas J Weise , Nicholas J Turner , Nigel S Scrutton

Graphene-aramid nanocomposite fibres via superacid co-processing.

Chemical communications (Cambridge, England)

Avec: Aled D Roberts , Paul Kelly , Jennifer Bain , John J Morrison , Ian Wimpenny , Mike Barrow , Robert T Woodward , Matthieu Gresil , Christopher Blanford , Sam Hay , Jonny J Blaker , Steve G Yeates , Nigel S Scrutton

Photochemical Spin Dynamics of the Vitamin B

The journal of physical chemistry. B

Avec: Valentina Lukinović , Jonathan R Woodward , Teresa C Marrafa , Muralidharan Shanmugam , Derren J Heyes , Samantha J O Hardman , Nigel S Scrutton , Sam Hay , Alistair J Fielding , Alex R Jones

From Bugs to Bioplastics: Total (+)-Dihydrocarvide Biosynthesis by Engineered Escherichia coli.

Chembiochem : a European journal of chemical biology

Avec: Gabriel A Ascue Avalos , Helen S Toogood , Shirley Tait , Hanan L Messiha , Nigel S Scrutton

Radical-based photoinactivation of fatty acid photodecarboxylases.

Analytical biochemistry

Avec: Balaji Lakavath , Tobias M Hedison , Derren J Heyes , Muralidharan Shanmugam , Michiyo Sakuma , Robin Hoeven , Viranga Tilakaratna , Nigel S Scrutton

Active Intermediates in Copper Nitrite Reductase Reactions Probed by a Cryotrapping-Electron Paramagnetic Resonance Approach.

Angewandte Chemie (International ed. in English)

Avec: Tobias M Hedison , Muralidharan Shanmugam , Derren J Heyes , Ruth Edge , Nigel S Scrutton

Ultrafast Vibrational Energy Transfer between Protein and Cofactor in a Flavoenzyme.

The journal of physical chemistry. B

Avec: Samantha J O Hardman , Andreea I Iorgu , Derren J Heyes , Nigel S Scrutton , Igor V Sazanovich , Sam Hay

Photochemical Mechanism of Light-Driven Fatty Acid Photodecarboxylase.

ACS catalysis

Avec: Derren J Heyes , Balaji Lakavath , Samantha J O Hardman , Michiyo Sakuma , Tobias M Hedison , Nigel S Scrutton

Consolidated Bioprocessing: Synthetic Biology Routes to Fuels and Fine Chemicals.

Microorganisms

Avec: Alec Banner , Helen S Toogood , Nigel S Scrutton

Molecular Determinants of Carbocation Cyclisation in Bacterial Monoterpene Synthases.

Chembiochem : a European journal of chemical biology

Avec: Nicole G H Leferink , Andrés M Escorcia , Bodi R Ouwersloot , Linus O Johanissen , Sam Hay , Marc W van der Kamp , Nigel S Scrutton

GeneORator: An Efficient Method for the Systematic Mutagenesis of Entire Genes.

Methods in molecular biology (Clifton, N.J.)

Avec: Lucy Green , Nigel S Scrutton , Andrew Currin

Combinatorial use of environmental stresses and genetic engineering to increase ethanol titres in cyanobacteria.

Biotechnology for biofuels

Avec: Fraser Andrews , Matthew Faulkner , Helen S Toogood , Nigel S Scrutton

Ectoine hyperproduction by engineered Halomonas bluephagenesis.

Metabolic engineering

Avec: Qitiao Hu , Simian Sun , Zhongnan Zhang , Wei Liu , Xueqing Yi , Hongtao He , Nigel S Scrutton , Guo-Qiang Chen

Combined Pulsed Electron Double Resonance EPR and Molecular Dynamics Investigations of Calmodulin Suggest Effects of Crowding Agents on Protein Structures.

Biochemistry

Avec: Andrew M Stewart , Muralidharan Shanmugam , Roger J Kutta , Nigel S Scrutton , Janet E Lovett , Sam Hay

Structure-Based Design of Small Imine Reductase Panels for Target Substrates.

ACS catalysis

Avec: Yuqi Yu , Arnau Rué Casamajo , William Finnigan , Christian Schnepel , Rhys Barker , Charlotte Morrill , Rachel S Heath , Leonardo De Maria , Nicholas J Turner , Nigel S Scrutton

Nonsterile microbial production of chemicals based on Halomonas spp.

Current opinion in biotechnology

Avec: Jing Zhang , Xu Yan , Helen Park , Nigel S Scrutton , Tao Chen , Guo-Qiang Chen

Arabinose as an overlooked sugar for microbial bioproduction of chemical building blocks.

Critical reviews in biotechnology

Avec: Vinod Kumar , Deepti Agrawal , Rajesh Reddy Bommareddy , M Ahsanul Islam , Samuel Jacob , Venkatesh Balan , Vijai Singh , Vijay Kumar Thakur , Naveen Kumar Navani , Nigel S Scrutton

A growth-coupling strategy for improving the stability of terpenoid bioproduction in Escherichia coli.

Microbial cell factories

Avec: Jing Chong Tan , Qitiao Hu , Nigel S Scrutton

Rapid prototyping of microbial production strains for the biomanufacture of potential materials monomers.

Metabolic engineering

Avec: Christopher J Robinson , Pablo Carbonell , Adrian J Jervis , Cunyu Yan , Katherine A Hollywood , Mark S Dunstan , Andrew Currin , Neil Swainston , Reynard Spiess , Sandra Taylor , Paul Mulherin , Steven Parker , William Rowe , Nicholas E Matthews , Kirk J Malone , Rosalind Le Feuvre , Philip Shapira , Perdita Barran , Nicholas J Turner , Jason Micklefield , Rainer Breitling , Eriko Takano , Nigel S Scrutton

Exploring novel bacterial terpene synthases.

PloS one

Avec: Gajendar Komati Reddy , Nicole G H Leferink , Maiko Umemura , Syed T Ahmed , Rainer Breitling , Nigel S Scrutton , Eriko Takano

A brain-permeable inhibitor of the neurodegenerative disease target kynurenine 3-monooxygenase prevents accumulation of neurotoxic metabolites.

Communications biology

Avec: Shaowei Zhang , Michiyo Sakuma , Girdhar S Deora , Colin W Levy , Alex Klausing , Carlo Breda , Kevin D Read , Chris D Edlin , Benjamin P Ross , Marina Wright Muelas , Philip J Day , Stephen O'Hagan , Douglas B Kell , Robert Schwarcz , David Leys , Derren J Heyes , Flaviano Giorgini , Nigel S Scrutton

Tripping the light fantastic in membrane redox biology: linking dynamic structures to function in ER electron transfer chains.

The FEBS journal

Avec: Tobias M Hedison , Nigel S Scrutton

Equatorial Active Site Compaction and Electrostatic Reorganization in Catechol-

ACS catalysis

Avec: Sylwia Czarnota , Linus O Johannissen , Nicola J Baxter , Felix Rummel , Alex L Wilson , Matthew J Cliff , Colin W Levy , Nigel S Scrutton , Jonathan P Waltho , Sam Hay

Solvent-slaved protein motions accompany proton coupled electron transfer reactions catalysed by copper nitrite reductase.

Chemical communications (Cambridge, England)

Avec: Tobias M Hedison , Derren J Heyes , Muralidharan Shanmugam , Andreea I Iorgu , Nigel S Scrutton

What are the signatures of tunnelling in enzyme-catalysed reactions?

Faraday discussions

Avec: Linus O Johannissen , Andreea I Iorgu , Nigel S Scrutton , Sam Hay

C3 and C6 Modification-Specific OYE Biotransformations of Synthetic Carvones and Sequential BVMO Chemoenzymatic Synthesis of Chiral Caprolactones.

Chemistry (Weinheim an der Bergstrasse, Germany)

Avec: Issa S Issa , Helen S Toogood , Linus O Johannissen , James Raftery , Nigel S Scrutton , John M Gardiner

Discovery, Characterisation, Engineering and Applications of Ene Reductases for Industrial Biocatalysis.

ACS catalysis

Avec: Helen S Toogood , Nigel S Scrutton

A plasmid toolset for CRISPR-mediated genome editing and CRISPRi gene regulation in Escherichia coli.

Microbial biotechnology

Avec: Adrian J Jervis , Erik K R Hanko , Mark S Dunstan , Christopher J Robinson , Eriko Takano , Nigel S Scrutton

Production of the Fragrance Geraniol in Peroxisomes of a Product-Tolerant Baker's Yeast.

Frontiers in bioengineering and biotechnology

Avec: Jennifer Gerke , Holm Frauendorf , Dominik Schneider , Maxim Wintergoller , Thomas Hofmeister , Anja Poehlein , Ziga Zebec , Eriko Takano , Nigel S Scrutton , Gerhard H Braus

Thermal, electrochemical and photochemical reactions involving catalytically versatile ene reductase enzymes.

The Enzymes

Avec: Helen S Toogood , Nigel S Scrutton

Isopentenol Utilization Pathway for the Production of Linalool in Escherichia coli Using an Improved Bacterial Linalool/Nerolidol Synthase.

Chembiochem : a European journal of chemical biology

Avec: Clara A Ferraz , Nicole G H Leferink , Iaroslav Kosov , Nigel S Scrutton

Réseau de co-auteurs

Derren J Heyes 25 collaborations

Sam Hay 19 collaborations

Eriko Takano 17 collaborations

Linus O Johannissen 11 collaborations

Tobias M Hedison 11 collaborations

Helen S Toogood 11 collaborations

Samantha J O Hardman 10 collaborations

Shaowei Zhang 9 collaborations

Andrew Currin 9 collaborations

Andreea I Iorgu 8 collaborations

Rainer Breitling 8 collaborations

Adrian J Jervis 8 collaborations

Mark S Dunstan 8 collaborations

Cunyu Yan 8 collaborations

Nicole G H Leferink 8 collaborations

Muralidharan Shanmugam 8 collaborations

Pablo Carbonell 7 collaborations

Christopher J Robinson 7 collaborations

Katherine A Hollywood 7 collaborations

Michiyo Sakuma 6 collaborations

David Leys 6 collaborations

Guo-Qiang Chen 6 collaborations

Aoife Taylor 5 collaborations

Colin W Levy 5 collaborations

Robin Hoeven 5 collaborations

Neil Swainston 5 collaborations

Helen Park 5 collaborations

Aled D Roberts 4 collaborations

Jonny J Blaker 4 collaborations

Rosalind Le Feuvre 4 collaborations

Sandra Taylor 4 collaborations

Helen Toogood 4 collaborations

Matthew Faulkner 4 collaborations

William Finnigan 3 collaborations

Paul Kelly 3 collaborations

Matthew J Cliff 3 collaborations

Yuqi Yu 3 collaborations

Giorgio Schirò 3 collaborations

Martin Weik 3 collaborations

Igor V Sazanovich 3 collaborations

Flaviano Giorgini 3 collaborations

Marc W van der Kamp 3 collaborations

Nicholas J Turner 3 collaborations

Robert R Eady 2 collaborations

Svetlana V Antonyuk 2 collaborations

S Samar Hasnain 2 collaborations

Emmanuel Wolde-Michael 2 collaborations

Rehana Sung 2 collaborations

Jonathan P Waltho 2 collaborations

Qi Cheng 2 collaborations

Paul Mulherin 2 collaborations

Gajendar Komati Reddy 2 collaborations

Shirley Tait 2 collaborations

Harshwardhan Poddar 2 collaborations

Jean-Loup Faulon 2 collaborations

Daniel Kracher 2 collaborations

Mohamed Amer 2 collaborations

Hanan L Messiha 2 collaborations

Hongtao He 2 collaborations

Xu Yan 2 collaborations

Lewis J Kearsey 2 collaborations

Nicole Prandi 2 collaborations

Reynard Spiess 2 collaborations

Anthony P Green 2 collaborations

A D Roberts 2 collaborations

R Breitling 2 collaborations

E Takano 2 collaborations

N S Scrutton 2 collaborations

J J Blaker 2 collaborations

S Hay 2 collaborations

Vijaykumar Karuppiah 2 collaborations

Kara E Ranaghan 2 collaborations

Adrian J Mulholland 2 collaborations

Jonathan R Woodward 2 collaborations

Alex R Jones 2 collaborations

William Rowe 2 collaborations

Perdita Barran 2 collaborations

Leonardo De Maria 2 collaborations

Jason Micklefield 2 collaborations

Ziga Zebec 2 collaborations

Balaji Lakavath 2 collaborations

Qitiao Hu 2 collaborations

Alan R F Godwin 1 collaboration

Thomas A Jowitt 1 collaboration

Clair Baldock 1 collaboration

Rajesh T Shenoy 1 collaboration

Karl Fisher 1 collaboration

Gareth S A Wright 1 collaboration

Padmaja P Nampi 1 collaboration

Alexander Vakurov 1 collaboration

Lewis E Mackenzie 1 collaboration

Paul A Millner 1 collaboration

Gin Jose 1 collaboration

Sikha Saha 1 collaboration

Nathan Hillson 1 collaboration

Mark Caddick 1 collaboration

Yizhi Cai 1 collaboration

Jose A Carrasco 1 collaboration

Matthew Wook Chang 1 collaboration

Natalie C Curach 1 collaboration

David J Bell 1 collaboration

Douglas C Friedman 1 collaboration

Xiongfei Fu 1 collaboration

Nicholas D Gold 1 collaboration

Markus J Herrgård 1 collaboration

Maciej B Holowko 1 collaboration

James R Johnson 1 collaboration

Richard A Johnson 1 collaboration

Jay D Keasling 1 collaboration

Richard I Kitney 1 collaboration

Akihiko Kondo 1 collaboration

Chenli Liu 1 collaboration

Vincent J J Martin 1 collaboration

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