Exploiting Single Domain Antibodies as Regulatory Parts to Modulate Monoterpenoid Production in


Journal

ACS synthetic biology
ISSN: 2161-5063
Titre abrégé: ACS Synth Biol
Pays: United States
ID NLM: 101575075

Informations de publication

Date de publication:
16 10 2020
Historique:
pubmed: 16 9 2020
medline: 31 7 2021
entrez: 15 9 2020
Statut: ppublish

Résumé

Synthetic biology and metabolic engineering offer potentially green and attractive routes to the production of high value compounds. The provision of high-quality parts and pathways is crucial in enabling the biosynthesis of chemicals using synthetic biology. While a number of regulatory parts that provide control at the transcriptional and translational level have been developed, relatively few exist at the protein level. Single domain antibodies (sdAb) such as camelid heavy chain variable fragments (V

Identifiants

pubmed: 32927940
doi: 10.1021/acssynbio.0c00375
doi:

Substances chimiques

Acyclic Monoterpenes 0
Bacterial Proteins 0
Codon 0
Immunoglobulin Heavy Chains 0
Single-Domain Antibodies 0
linalool D81QY6I88E
Hydro-Lyases EC 4.2.1.-
S-linalool synthase EC 4.2.1.-

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2828-2839

Subventions

Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/N503976/1
Pays : United Kingdom

Auteurs

Jonathan Wilkes (J)

Manchester Institute of Biotechnology, Department of Chemistry, School of Natural Sciences, The University of Manchester, Manchester, M13 9PL, United Kingdom.

Anthony Scott-Tucker (A)

UCB Pharma Ltd., Slough, SL1 3WE, United Kingdom.

Mike Wright (M)

UCB Pharma Ltd., Slough, SL1 3WE, United Kingdom.

Tom Crabbe (T)

UCB Pharma Ltd., Slough, SL1 3WE, United Kingdom.

Nigel S Scrutton (NS)

Manchester Institute of Biotechnology, Department of Chemistry, School of Natural Sciences, The University of Manchester, Manchester, M13 9PL, United Kingdom.

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Classifications MeSH