Catalytic Mechanism of Aromatic Nitration by Cytochrome P450 TxtE: Involvement of a Ferric-Peroxynitrite Intermediate.


Journal

Journal of the American Chemical Society
ISSN: 1520-5126
Titre abrégé: J Am Chem Soc
Pays: United States
ID NLM: 7503056

Informations de publication

Date de publication:
16 09 2020
Historique:
pubmed: 20 8 2020
medline: 16 4 2021
entrez: 20 8 2020
Statut: ppublish

Résumé

The cytochromes P450 are heme-dependent enzymes that catalyze many vital reaction processes in the human body related to biodegradation and biosynthesis. They typically act as mono-oxygenases; however, the recently discovered P450 subfamily TxtE utilizes O

Identifiants

pubmed: 32811149
doi: 10.1021/jacs.0c05070
pmc: PMC7586343
doi:

Substances chimiques

Ferric Compounds 0
Nitro Compounds 0
Peroxynitrous Acid 14691-52-2
Cytochrome P-450 Enzyme System 9035-51-2

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

15764-15779

Subventions

Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/H006265/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/H006281/1
Pays : United Kingdom

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Auteurs

Savvas Louka (S)

The Manchester Institute of Biotechnology, The University of Manchester, 131 Princess Street, Manchester M1 7DN, United Kingdom.
Department of Chemical Engineering and Analytical Science, The University of Manchester, Oxford Road, Mancheste M13 9PL, United Kingdom.

Sarah M Barry (SM)

Department of Chemistry, University of Warwick, Coventry CV4 7AL, United Kingdom.

Derren J Heyes (DJ)

The Manchester Institute of Biotechnology, The University of Manchester, 131 Princess Street, Manchester M1 7DN, United Kingdom.
Department of Chemistry, The University of Manchester, Oxford Road, Manchester M13 9PL, United Kingdom.

M Qadri E Mubarak (MQE)

The Manchester Institute of Biotechnology, The University of Manchester, 131 Princess Street, Manchester M1 7DN, United Kingdom.
Department of Chemical Engineering and Analytical Science, The University of Manchester, Oxford Road, Mancheste M13 9PL, United Kingdom.

Hafiz Saqib Ali (HS)

The Manchester Institute of Biotechnology, The University of Manchester, 131 Princess Street, Manchester M1 7DN, United Kingdom.
Department of Chemistry, The University of Manchester, Oxford Road, Manchester M13 9PL, United Kingdom.

Lona M Alkhalaf (LM)

Department of Chemistry, University of Warwick, Coventry CV4 7AL, United Kingdom.

Andrew W Munro (AW)

The Manchester Institute of Biotechnology, The University of Manchester, 131 Princess Street, Manchester M1 7DN, United Kingdom.
Department of Chemistry, The University of Manchester, Oxford Road, Manchester M13 9PL, United Kingdom.

Nigel S Scrutton (NS)

The Manchester Institute of Biotechnology, The University of Manchester, 131 Princess Street, Manchester M1 7DN, United Kingdom.
Department of Chemistry, The University of Manchester, Oxford Road, Manchester M13 9PL, United Kingdom.

Gregory L Challis (GL)

Department of Chemistry, University of Warwick, Coventry CV4 7AL, United Kingdom.
Department of Biochemistry and Molecular Biology, Monash University, Clayton VIC 3800, Australia.
ARC Centre for Excellence for Innovations in Peptide and Protein Science, Monash University, Clayton, VIC 3800, Australia.

Sam P de Visser (SP)

The Manchester Institute of Biotechnology, The University of Manchester, 131 Princess Street, Manchester M1 7DN, United Kingdom.
Department of Chemical Engineering and Analytical Science, The University of Manchester, Oxford Road, Mancheste M13 9PL, United Kingdom.

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