Inflammation control and improvement of cognitive function in COVID-19 infections: is there a role for kynurenine 3-monooxygenase inhibition?

Animals COVID-19 / immunology Cognition / drug effects Humans Inflammation / metabolism Kynurenine / metabolism Kynurenine 3-Monooxygenase / antagonists & inhibitors Neuroprotective Agents / pharmacology Signal Transduction Sulfonamides / pharmacology Thiazoles / pharmacology Tryptophan / metabolism

Journal

Drug discovery today
ISSN: 1878-5832
Titre abrégé: Drug Discov Today
Pays: England
ID NLM: 9604391

Informations de publication

Date de publication:
06 2021
Historique:
received: 04 11 2020
revised: 26 01 2021
accepted: 10 02 2021
pubmed: 21 2 2021
medline: 30 6 2021
entrez: 20 2 2021
Statut: ppublish

Résumé

The novel respiratory virus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19), emerged during late 2019 and spread rapidly across the world. It is now recognised that the nervous system can be affected in COVID-19, with several studies reporting long-term cognitive problems in patients. The metabolic pathway of tryptophan degradation, known as the kynurenine pathway (KP), is significantly activated in patients with COVID-19. KP metabolites have roles in regulating both inflammatory/immune responses and neurological functions. In this review, we speculate on the effects of KP activation in patients with COVID-19, and how modulation of this pathway might impact inflammation and reduce neurological symptoms.

Identifiants

DOI: 10.1016/j.drudis.2021.02.009 PMID: 33609782 PMC: PMC7889466
pubmed: 33609782
pii: S1359-6446(21)00075-1
doi: 10.1016/j.drudis.2021.02.009
pmc: PMC7889466
pii:
doi:

Substances chimiques

Neuroprotective Agents 0
Ro 61-8048 0
Sulfonamides 0
Thiazoles 0
Kynurenine 343-65-7
Tryptophan 8DUH1N11BX
Kynurenine 3-Monooxygenase EC 1.14.13.9

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

1473-1481

Informations de copyright

Copyright © 2021 Elsevier Ltd. All rights reserved.

Références

J Med Chem. 1997 Dec 19;40(26):4378-85
pubmed: 9435907
J Hepatol. 2005 Oct;43(4):614-22
pubmed: 16237784
J Neuroimmunol. 2019 Oct 15;335:577022
pubmed: 31445380
Nat Med. 2020 Jul;26(7):1017-1032
pubmed: 32651579
Front Cell Neurosci. 2015 May 18;9:178
pubmed: 26041992
Crit Care Explor. 2020 Oct 21;2(10):e0272
pubmed: 33134953
Clin Exp Immunol. 2015 Jun;180(3):484-98
pubmed: 25605587
N Engl J Med. 2021 Feb 25;384(8):693-704
pubmed: 32678530
J Med Chem. 1994 Mar 4;37(5):647-55
pubmed: 8126705
J Neurochem. 1995 Feb;64(2):932-5
pubmed: 7830088
Nat Med. 2016 Feb;22(2):202-9
pubmed: 26752518
Clin Infect Dis. 2021 Nov 2;73(9):e3102-e3105
pubmed: 32770235
Clin Chem. 1998 Apr;44(4):858-62
pubmed: 9554499
Exp Mol Med. 2019 Feb 13;51(2):1-14
pubmed: 30760699
Cell Death Differ. 2002 Oct;9(10):1069-77
pubmed: 12232795
Gene. 2007 Jul 1;396(1):203-13
pubmed: 17499941
AIDS. 1998 Mar 5;12(4):355-63
pubmed: 9520164
Int J Tryptophan Res. 2013 Nov 25;6:89-96
pubmed: 24324341
Proc Natl Acad Sci U S A. 2020 Jun 9;117(23):13117-13126
pubmed: 32434907
J Proteome Res. 2020 Nov 6;19(11):4442-4454
pubmed: 32806897
Cell. 2011 Jun 10;145(6):863-74
pubmed: 21640374
Science. 1983 Jan 21;219(4582):316-8
pubmed: 6849138
Commun Biol. 2019 Jul 24;2:271
pubmed: 31372510
Psychopharmacology (Berl). 2012 Apr;220(3):627-37
pubmed: 22038535
J Immunol Regen Med. 2019 Sep;5:
pubmed: 31788580
Neurotoxicol Teratol. 2011 Sep-Oct;33(5):538-47
pubmed: 21763768
J Neurochem. 1989 Apr;52(4):1319-28
pubmed: 2538568
J Gen Virol. 2013 Jul;94(Pt 7):1451-1461
pubmed: 23580425
Neurology. 2020 Sep 29;95(13):e1868-e1882
pubmed: 32680942
J Neurosci. 2001 Oct 1;21(19):7463-73
pubmed: 11567036
Neurotox Res. 2009 Jul;16(1):77-86
pubmed: 19526301
Brain. 2009 May;132(Pt 5):1259-67
pubmed: 19339256
Sci Signal. 2021 Jul 06;14(690):
pubmed: 34230210
J Exp Med. 2002 Aug 19;196(4):459-68
pubmed: 12186838
J Neurochem. 1996 Mar;66(3):996-1004
pubmed: 8769859
Biochim Biophys Acta. 2016 Nov;1860(11 Pt A):2345-2354
pubmed: 27392942
World J Gastroenterol. 2020 Mar 7;26(9):918-932
pubmed: 32206003
Lancet Psychiatry. 2020 Oct;7(10):875-882
pubmed: 32593341
Adv Exp Med Biol. 2003;527:105-12
pubmed: 15206722
J Neuroinflammation. 2020 Jun 6;17(1):176
pubmed: 32505212
Semin Cell Dev Biol. 2015 Apr;40:134-41
pubmed: 25773161
Neuroscience. 1994 Nov;63(2):471-87
pubmed: 7891859
JAMA. 2020 Aug 11;324(6):603-605
pubmed: 32644129
Nat Rev Drug Discov. 2020 Nov;19(11):745
pubmed: 33009526
JCI Insight. 2020 Jul 23;5(14):
pubmed: 32559180
Neurol Res Pract. 2020 Dec 2;2:51
pubmed: 33283160
Brain Behav Immun. 2020 Oct;89:594-600
pubmed: 32738287
FEBS J. 2011 Nov;278(22):4425-34
pubmed: 22032336
J Neural Transm (Vienna). 2012 Feb;119(2):133-9
pubmed: 22215208
Ann Neurol. 1991 Feb;29(2):202-9
pubmed: 1826418
N Engl J Med. 2020 Jun 4;382(23):2268-2270
pubmed: 32294339
Int J Tryptophan Res. 2011;4:29-37
pubmed: 22084601
J Immunol. 2010 Sep 15;185(6):3190-8
pubmed: 20720200
J Immunol. 1989 Nov 1;143(9):2969-73
pubmed: 2553814
J Infect. 2020 Dec;81(6):e4-e6
pubmed: 32853602
Toxicol Sci. 2010 May;115(1):89-97
pubmed: 20106948
J Immunol. 2019 Aug 15;203(4):899-910
pubmed: 31285277
J Biol Chem. 2006 Aug 4;281(31):22021-22028
pubmed: 16754668
Int J Tryptophan Res. 2012;5:49-64
pubmed: 23300346
Restor Neurol Neurosci. 2020;38(4):343-354
pubmed: 32597823
Immunol Lett. 2017 Jan;181:94-100
pubmed: 27889626
J Neurochem. 1998 Jan;70(1):299-307
pubmed: 9422375
Prog Neuropsychopharmacol Biol Psychiatry. 2019 Mar 8;89:286-294
pubmed: 30267854
Infect Immun. 2005 Aug;73(8):5249-51
pubmed: 16041050
Front Immunol. 2020 Jun 26;11:1636
pubmed: 32670298
J Exp Med. 1999 May 3;189(9):1363-72
pubmed: 10224276
Neurosci Lett. 1995 Feb 24;187(1):9-12
pubmed: 7617307
J Virol. 2007 Apr;81(7):3662-6
pubmed: 17229698
J Exp Med. 2002 Aug 19;196(4):447-57
pubmed: 12186837
Brain Behav Immun. 2014 Oct;41:173-81
pubmed: 24878170
Lancet Neurol. 2020 Sep;19(9):767-783
pubmed: 32622375
J Neurochem. 1991 Jun;56(6):2007-17
pubmed: 1827495
J Med Chem. 2015 Feb 12;58(3):1159-83
pubmed: 25590515
Blood. 2009 Oct 8;114(15):3235-43
pubmed: 19625705
Drug Metab Dispos. 2012 Dec;40(12):2297-306
pubmed: 22942319
Hum Vaccin Immunother. 2022 Nov 30;18(5):2048622
pubmed: 35348437
Cell. 2020 Jul 9;182(1):59-72.e15
pubmed: 32492406
Adv Exp Med Biol. 2003;527:621-8
pubmed: 15206781
Psychopharmacology (Berl). 2020 Jun;237(6):1723-1735
pubmed: 32162104
Hippocampus. 2019 Feb;29(2):73-77
pubmed: 30311334
JAMA Neurol. 2020 Jun 1;77(6):683-690
pubmed: 32275288
Biology (Basel). 2020 Aug 27;9(9):
pubmed: 32867244

Auteurs

Mary Ew Collier (ME)

Department of Genetics and Genome Biology, University of Leicester, Leicester LE1 7RH, UK. Electronic address: mec40@leicester.ac.uk.

Shaowei Zhang (S)

Manchester Institute of Biotechnology, Department of Chemistry, School of Natural Sciences, The University of Manchester, 131 Princess Street, Manchester M1 7DN, UK.

Nigel S Scrutton (NS)

Manchester Institute of Biotechnology, Department of Chemistry, School of Natural Sciences, The University of Manchester, 131 Princess Street, Manchester M1 7DN, UK.

Flaviano Giorgini (F)

Department of Genetics and Genome Biology, University of Leicester, Leicester LE1 7RH, UK.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Inflammation control and improvement of...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › COVID-19 › Inflammation control and improvement of...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Cognition › Inflammation control and improvement of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Inflammation control and improvement of...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Inflammation control and improvement of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Cynurénine › Inflammation control and improvement of...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxygénases › Mixed function oxygenases › Kynurenine 3-monooxygenase › Inflammation control and improvement of...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Neuroprotecteurs › Inflammation control and improvement of...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Inflammation control and improvement of...
questionsmedicales.fr › Composés chimiques organiques › Composés du soufre › Sulfones › Sulfonamides › Inflammation control and improvement of...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Thiazoles › Inflammation control and improvement of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés essentiels › Tryptophane › Inflammation control and improvement of...