Schizophrenia Exhibits Bi-directional Brain-Wide Alterations in Cortico-Striato-Cerebellar Circuits.
CSTC circuits
connectivity
fMRI
machine learning
resting-state
Journal
Cerebral cortex (New York, N.Y. : 1991)
ISSN: 1460-2199
Titre abrégé: Cereb Cortex
Pays: United States
ID NLM: 9110718
Informations de publication
Date de publication:
17 12 2019
17 12 2019
Historique:
received:
06
08
2018
revised:
17
10
2018
pubmed:
4
6
2019
medline:
21
10
2020
entrez:
4
6
2019
Statut:
ppublish
Résumé
Distributed neural dysconnectivity is considered a hallmark feature of schizophrenia (SCZ), yet a tension exists between studies pinpointing focal disruptions versus those implicating brain-wide disturbances. The cerebellum and the striatum communicate reciprocally with the thalamus and cortex through monosynaptic and polysynaptic connections, forming cortico-striatal-thalamic-cerebellar (CSTC) functional pathways that may be sensitive to brain-wide dysconnectivity in SCZ. It remains unknown if the same pattern of alterations persists across CSTC systems, or if specific alterations exist along key functional elements of these networks. We characterized connectivity along major functional CSTC subdivisions using resting-state functional magnetic resonance imaging in 159 chronic patients and 162 matched controls. Associative CSTC subdivisions revealed consistent brain-wide bi-directional alterations in patients, marked by hyper-connectivity with sensory-motor cortices and hypo-connectivity with association cortex. Focusing on the cerebellar and striatal components, we validate the effects using data-driven k-means clustering of voxel-wise dysconnectivity and support vector machine classifiers. We replicate these results in an independent sample of 202 controls and 145 patients, additionally demonstrating that these neural effects relate to cognitive performance across subjects. Taken together, these results from complementary approaches implicate a consistent motif of brain-wide alterations in CSTC systems in SCZ, calling into question accounts of exclusively focal functional disturbances.
Identifiants
pubmed: 31157363
pii: 5510259
doi: 10.1093/cercor/bhy306
pmc: PMC6917525
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4463-4487Subventions
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Organisme : NIH HHS
ID : DP5 OD012109
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH077862
Pays : United States
Informations de copyright
© The Author(s) 2019. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.
Références
Nat Neurosci. 2014 Dec;17(12):1661-3
pubmed: 25383900
Schizophr Bull. 2012 Sep;38(5):967-80
pubmed: 21415225
Biol Psychiatry. 2018 Mar 15;83(6):473-474
pubmed: 29429501
J Psychiatr Res. 2010 Jul;44(10):629-39
pubmed: 20060129
Biol Psychiatry. 2005 Sep 1;58(5):408-16
pubmed: 16023618
Psychopharmacology (Berl). 2003 Sep;169(3-4):215-33
pubmed: 12955285
Arch Gen Psychiatry. 1982 Sep;39(9):991-7
pubmed: 7115016
Schizophr Bull. 2010 Jul;36(4):713-22
pubmed: 18990709
JAMA Psychiatry. 2016 Aug 1;73(8):862-70
pubmed: 27145361
Neuroimage. 2009 Jan 1;44(1):83-98
pubmed: 18501637
Am J Psychiatry. 2010 Jul;167(7):748-51
pubmed: 20595427
Front Hum Neurosci. 2012 May 23;6:137
pubmed: 22654746
Biol Psychiatry. 2017 May 15;81(10):818-820
pubmed: 28063469
Arch Gen Psychiatry. 2005 Apr;62(4):379-86
pubmed: 15809405
Schizophr Res. 2004 Jun 1;68(2-3):283-97
pubmed: 15099610
Cereb Cortex. 2014 Apr;24(4):859-72
pubmed: 23203979
Proc Natl Acad Sci U S A. 2016 Jan 12;113(2):E219-28
pubmed: 26699491
Biol Psychiatry. 2011 May 1;69(9):847-56
pubmed: 21195388
Front Hum Neurosci. 2015 Mar 18;9:134
pubmed: 25852520
J Neurosci. 2014 Sep 3;34(36):12192-205
pubmed: 25186762
Neuroimage. 2016 Nov 1;141:502-516
pubmed: 27288322
Neuroimage. 2014 May 15;92:381-97
pubmed: 24530839
Schizophr Bull. 2015 Nov;41(6):1336-48
pubmed: 26012519
Neuroimage. 2012 Jan 2;59(1):238-47
pubmed: 21840407
Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9985-90
pubmed: 8790444
Schizophr Bull. 2009 May;35(3):509-27
pubmed: 19155345
Neuroimage. 2014 Jan 1;84:299-306
pubmed: 24004694
Neuron. 2006 Feb 16;49(4):603-15
pubmed: 16476668
Am J Psychiatry. 2016 Jan;173(1):69-77
pubmed: 26315980
J Comp Neurol. 1993 Nov 1;337(1):1-31
pubmed: 7506270
Cereb Cortex. 2014 Dec;24(12):3116-30
pubmed: 23825317
Arch Gen Psychiatry. 2009 Jan;66(1):13-20
pubmed: 19124684
Neuroimage. 2013 Oct 15;80:105-24
pubmed: 23668970
Schizophr Bull. 2005 Oct;31(4):875-81
pubmed: 16079388
Am J Psychiatry. 2012 Oct;169(10):1092-9
pubmed: 23032387
Science. 1975 Jun 20;188(4194):1217-9
pubmed: 1145194
Biol Psychiatry. 2011 May 15;69(10):967-73
pubmed: 21193174
Schizophr Bull. 1987;13(2):261-76
pubmed: 3616518
J Neurophysiol. 2012 Oct;108(8):2242-63
pubmed: 22832566
Neuroscientist. 2001 Aug;7(4):315-24
pubmed: 11488397
Hum Brain Mapp. 1996;4(2):113-21
pubmed: 20408191
Biol Psychiatry. 2014 Apr 15;75(8):595-605
pubmed: 24314349
Cereb Cortex. 2009 Jun;19(6):1239-55
pubmed: 19020203
Arch Gen Psychiatry. 2009 Nov;66(11):1189-200
pubmed: 19884607
Biol Psychiatry. 2006 May 15;59(10):929-39
pubmed: 16427028
Am J Psychiatry. 2016 Apr 1;173(4):373-84
pubmed: 26651391
J Neurophysiol. 2011 Nov;106(5):2322-45
pubmed: 21795627
Biol Psychiatry. 2010 Feb 1;67(3):255-62
pubmed: 19897178
Schizophr Res. 2007 Jul;93(1-3):79-89
pubmed: 17383859
JAMA Psychiatry. 2017 Jun 1;74(6):605-613
pubmed: 28467520
Trends Pharmacol Sci. 2011 Sep;32(9):507-13
pubmed: 21700346
Neuroimage. 2013 Aug 1;76:439-41
pubmed: 22440651
Trends Neurosci. 2007 May;30(5):220-7
pubmed: 17400299
Can J Psychiatry. 2002 Feb;47(1):27-38
pubmed: 11873706
Biol Psychiatry Cogn Neurosci Neuroimaging. 2017 May;2(4):355-362
pubmed: 28584882
Front Psychiatry. 2013 Aug 29;4:95
pubmed: 24009589
Schizophr Res. 2014 Dec;160(1-3):67-72
pubmed: 25445623
Schizophr Bull. 2014 Jul;40(4):904-13
pubmed: 23861539
Arch Gen Psychiatry. 2005 Nov;62(11):1218-27
pubmed: 16275809
Proc Natl Acad Sci U S A. 1975 Nov;72(11):4376-80
pubmed: 1060115
J Magn Reson Imaging. 2011 Dec;34(6):1430-8
pubmed: 21976249
J Psychiatry Neurosci. 2005 May;30(3):178-86
pubmed: 15944742
Hum Brain Mapp. 2011 Jan;32(1):1-9
pubmed: 20205252
Neurosci Biobehav Rev. 2016 Aug;67:57-78
pubmed: 26743859
Neuroimage. 2011 Mar 1;55(1):8-23
pubmed: 21111053
Psychiatry Res. 2009 Mar 31;171(3):189-98
pubmed: 19230623
Neuroimage. 2009 Oct 1;47(4):1666-77
pubmed: 19524682
Am J Psychiatry. 2013 Nov;170(11):1263-74
pubmed: 23846857
Schizophr Bull. 2011 May;37(3):640-50
pubmed: 19920062
Neuroimage. 2007 Jan 1;34(1):235-42
pubmed: 17045492
Front Psychiatry. 2011 Dec 16;2:73
pubmed: 22203807
Proc Natl Acad Sci U S A. 2012 Oct 9;109(41):16720-5
pubmed: 23012427
JAMA Psychiatry. 2013 Nov;70(11):1143-51
pubmed: 24005188
Biol Psychiatry. 2010 Jul 1;68(1):17-24
pubmed: 20553749
Biol Psychiatry. 2013 Mar 15;73(6):565-73
pubmed: 22980587
Neuroimage. 2013 Feb 15;67:153-62
pubmed: 23194815
Am J Psychiatry. 1980 Feb;137(2):191-7
pubmed: 6101525
JAMA Psychiatry. 2014 Feb;71(2):109-18
pubmed: 24306091
Am J Psychiatry. 2010 Jul;167(7):818-27
pubmed: 20478875
Biol Psychiatry. 2011 Jul 1;70(1):43-50
pubmed: 21496789
Schizophr Bull. 2012 Sep;38(5):950-7
pubmed: 22355184
Arch Gen Psychiatry. 2001 Mar;58(3):280-8
pubmed: 11231835
Neuroimage. 2010 Jun;51(2):555-64
pubmed: 20206702
J Neurophysiol. 2011 Sep;106(3):1125-65
pubmed: 21653723
J Abnorm Psychol. 1992 Feb;101(1):37-44
pubmed: 1537971
Cereb Cortex. 2015 Sep;25(9):2383-94
pubmed: 24646613
JAMA Psychiatry. 2015 Sep;72(9):882-91
pubmed: 26267151
JAMA Psychiatry. 2015 Jan;72(1):5-13
pubmed: 25372846
Schizophr Res. 2006 Jul;85(1-3):280-7
pubmed: 16730429