Ubr1p-Cup9p-Ptr2p pathway involves in the sensitivity to readthrough compounds negamycin derivatives in budding yeast.
Dipeptide transporter
Ubr1p-Cup9p-Ptr2p pathway
negamycin
readthrough
Journal
Bioscience, biotechnology, and biochemistry
ISSN: 1347-6947
Titre abrégé: Biosci Biotechnol Biochem
Pays: England
ID NLM: 9205717
Informations de publication
Date de publication:
Oct 2019
Oct 2019
Historique:
pubmed:
5
6
2019
medline:
18
12
2019
entrez:
5
6
2019
Statut:
ppublish
Résumé
In this study, we found that dipeptide transporter Ptr2p is the putative transporter of read-through compounds (+)-negamycin derivatives TCP-126 and TCP-112, in budding yeast. Ptr2p expression and activity were correlated with the TCP-112 sensitivity, and dipeptide with high affinity to Ptr2p suppressed the TCP-112 activity. These results suggest that dipeptide transporter is one of the determinants of negamycin analogs sensitivity.
Identifiants
pubmed: 31159660
doi: 10.1080/09168451.2019.1625263
doi:
Substances chimiques
Amino Acids, Diamino
0
CUP9 protein, S cerevisiae
0
Homeodomain Proteins
0
Membrane Transport Proteins
0
PTR2 protein, S cerevisiae
0
Saccharomyces cerevisiae Proteins
0
Transcription Factors
0
negamycin
B15L87Q2HQ
UBR1 protein, S cerevisiae
EC 2.3.2.27
Ubiquitin-Protein Ligases
EC 2.3.2.27
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM