Cobalt nanoparticles as novel nanotherapeutics against Acanthamoeba castellanii.
Acanthamoeba
Antimicrobial
Cobalt nanoparticles
Cyst
Journal
Parasites & vectors
ISSN: 1756-3305
Titre abrégé: Parasit Vectors
Pays: England
ID NLM: 101462774
Informations de publication
Date de publication:
03 Jun 2019
03 Jun 2019
Historique:
received:
11
03
2019
accepted:
23
05
2019
entrez:
5
6
2019
pubmed:
5
6
2019
medline:
9
8
2019
Statut:
epublish
Résumé
Species of Acanthamoeba are facultative pathogens which can cause sight threatening Acanthamoeba keratitis and a rare but deadly brain infection, granulomatous amoebic encephalitis. Due to conversion of Acanthamoeba trophozoites to resistant cyst stage, most drugs are found to be ineffective at preventing recurrence of infection. This study was designed to test the antiacanthamoebic effects of different cobalt nanoparticles (CoNPs) against trophozoites and cysts, as well as parasite-mediated host cell cytotoxicity. Three different varieties of CoNPs were synthesized by utilizing hydrothermal and ultrasonication methods and were thoroughly characterized by X-ray diffraction and field emission scanning electron microscopy. Amoebicidal, encystation, excystation, and host cell cytopathogenicity assays were conducted to study the antiacanthamoebic effects of CoNPs. The results of the antimicrobial evaluation revealed that cobalt phosphate Co To our knowledge, these findings determined, for the first time, the effects of composition, size and morphology of CoNPs against A. castellanii. Co
Sections du résumé
BACKGROUND
BACKGROUND
Species of Acanthamoeba are facultative pathogens which can cause sight threatening Acanthamoeba keratitis and a rare but deadly brain infection, granulomatous amoebic encephalitis. Due to conversion of Acanthamoeba trophozoites to resistant cyst stage, most drugs are found to be ineffective at preventing recurrence of infection. This study was designed to test the antiacanthamoebic effects of different cobalt nanoparticles (CoNPs) against trophozoites and cysts, as well as parasite-mediated host cell cytotoxicity.
METHODS
METHODS
Three different varieties of CoNPs were synthesized by utilizing hydrothermal and ultrasonication methods and were thoroughly characterized by X-ray diffraction and field emission scanning electron microscopy. Amoebicidal, encystation, excystation, and host cell cytopathogenicity assays were conducted to study the antiacanthamoebic effects of CoNPs.
RESULTS
RESULTS
The results of the antimicrobial evaluation revealed that cobalt phosphate Co
CONCLUSIONS
CONCLUSIONS
To our knowledge, these findings determined, for the first time, the effects of composition, size and morphology of CoNPs against A. castellanii. Co
Identifiants
pubmed: 31159839
doi: 10.1186/s13071-019-3528-2
pii: 10.1186/s13071-019-3528-2
pmc: PMC6545699
doi:
Substances chimiques
Amebicides
0
Cobalt
3G0H8C9362
Types de publication
Journal Article
Langues
eng
Pagination
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