Idiopathic copper toxicosis: is abnormal copper metabolism a primary cause of this disease?
Carcinoma, Hepatocellular
/ drug therapy
Ceruloplasmin
/ metabolism
Chelating Agents
/ therapeutic use
Chemical and Drug Induced Liver Injury
/ drug therapy
Copper
/ metabolism
Female
Hepatocytes
/ metabolism
Hepatolenticular Degeneration
/ drug therapy
Humans
Liver
/ metabolism
Liver Cirrhosis
/ drug therapy
Liver Neoplasms
/ drug therapy
Liver Transplantation
Metal Metabolism, Inborn Errors
/ drug therapy
Trientine
/ therapeutic use
Young Adult
Copper
Hepatocellular carcinoma
Indian childhood cirrhosis
Mallory-Denk body
Wilson disease
Journal
Medical molecular morphology
ISSN: 1860-1499
Titre abrégé: Med Mol Morphol
Pays: Japan
ID NLM: 101239023
Informations de publication
Date de publication:
Mar 2020
Mar 2020
Historique:
received:
29
03
2019
accepted:
21
05
2019
pubmed:
5
6
2019
medline:
6
11
2020
entrez:
5
6
2019
Statut:
ppublish
Résumé
Idiopathic copper toxicosis (ICT) is characterized by marked copper deposition, Mallory-Denk body (MDB) formation and severe hepatic injury. Although the characteristics are apparently different from Wilson disease, large amounts of copper accumulate in the liver of the patients. We extensively treated a patient with ICT to reduce the body copper, however, the patient needed liver transplantation. Previous liver biopsy revealed high copper content. But extirpated liver contained an extremely small amount of copper, although MDBs and severe inflammation remained. These phenomena suggest abnormal copper metabolism is not the principle cause of ICT but some other abnormality must exist.
Identifiants
pubmed: 31161407
doi: 10.1007/s00795-019-00227-4
pii: 10.1007/s00795-019-00227-4
doi:
Substances chimiques
Chelating Agents
0
Copper
789U1901C5
Ceruloplasmin
EC 1.16.3.1
Trientine
SJ76Y07H5F
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
50-55Subventions
Organisme : JSPS KAKENHI
ID : 18K07988
Références
Arch Dis Child. 1987 Nov;62(11):1118-24
pubmed: 3318711
J Pediatr Gastroenterol Nutr. 1999 Nov;29(5):598-600
pubmed: 10554131
Med Mol Morphol. 2012 Jun;45(2):105-9
pubmed: 22718296
Hepatol Res. 2014 Apr;44(4):395-402
pubmed: 24450973
Gut. 1981 Apr;22(4):295-300
pubmed: 7239321
Indian J Med Res. 2013 Jun;137(6):1029-42
pubmed: 23852284
Am J Clin Nutr. 1996 May;63(5):842S-5S
pubmed: 8615372
J Hepatol. 2012 Mar;56(3):671-85
pubmed: 22340672
Exp Cell Res. 2007 Jun 10;313(10):2033-49
pubmed: 17531973
Hepatol Res. 2018 Aug;48(9):679-691
pubmed: 29882374
J Pediatr. 1999 Aug;135(2 Pt 1):189-96
pubmed: 10431113
Indian J Pediatr. 2013 Aug;80(8):651-4
pubmed: 23263972
Am J Clin Nutr. 1998 May;67(5 Suppl):1074S-1081S
pubmed: 9587155
Hepatology. 2008 Jun;47(6):2089-111
pubmed: 18506894
World J Gastroenterol. 2013 Apr 7;19(13):2110-3
pubmed: 23599633
Hepatology. 2004 Apr;39(4):963-9
pubmed: 15057900
Am J Clin Nutr. 1998 May;67(5 Suppl):1082S-1086S
pubmed: 9587156
Lancet. 1994 Oct 8;344(8928):1002-4
pubmed: 7934386
Exp Cell Res. 2016 Sep 10;347(1):192-200
pubmed: 27502587