Signal Transduction in Ribosome Biogenesis: A Recipe to Avoid Disaster.
Animals
Biomarkers
Cell Cycle
/ genetics
Disease Susceptibility
Eukaryotic Initiation Factor-2
/ metabolism
Extracellular Space
/ metabolism
Genes, myc
Humans
Phosphatidylinositol 3-Kinases
/ metabolism
Protein Biosynthesis
Proto-Oncogene Proteins c-akt
/ metabolism
RNA Editing
RNA Splicing
RNA, Ribosomal
/ genetics
Ribosomes
/ metabolism
Signal Transduction
Stress, Physiological
TOR Serine-Threonine Kinases
/ metabolism
Transcription, Genetic
MYC
PI3K-AKT-mTOR
PKR-eIF2α
RNA editing
RNA polymerase
RNA splicing
TP53
nucleus
oncology
translation
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
03 Jun 2019
03 Jun 2019
Historique:
received:
08
05
2019
revised:
29
05
2019
accepted:
30
05
2019
entrez:
6
6
2019
pubmed:
6
6
2019
medline:
26
11
2019
Statut:
epublish
Résumé
Energetically speaking, ribosome biogenesis is by far the most costly process of the cell and, therefore, must be highly regulated in order to avoid unnecessary energy expenditure. Not only must ribosomal RNA (rRNA) synthesis, ribosomal protein (RP) transcription, translation, and nuclear import, as well as ribosome assembly, be tightly controlled, these events must be coordinated with other cellular events, such as cell division and differentiation. In addition, ribosome biogenesis must respond rapidly to environmental cues mediated by internal and cell surface receptors, or stress (oxidative stress, DNA damage, amino acid depletion, etc.). This review examines some of the well-studied pathways known to control ribosome biogenesis (PI3K-AKT-mTOR, RB-p53, MYC) and how they may interact with some of the less well studied pathways (eIF2α kinase and RNA editing/splicing) in higher eukaryotes to regulate ribosome biogenesis, assembly, and protein translation in a dynamic manner.
Identifiants
pubmed: 31163577
pii: ijms20112718
doi: 10.3390/ijms20112718
pmc: PMC6600399
pii:
doi:
Substances chimiques
Biomarkers
0
Eukaryotic Initiation Factor-2
0
RNA, Ribosomal
0
MTOR protein, human
EC 2.7.1.1
Proto-Oncogene Proteins c-akt
EC 2.7.11.1
TOR Serine-Threonine Kinases
EC 2.7.11.1
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Leukemia Research Foundation
ID : Investigator Grant 2014
Organisme : Associazione Italiana per la Ricerca sul Cancro
ID : Investigator Grant 2015-17137
Organisme : Associazione Italiana per la Ricerca sul Cancro
ID : Investigator Grant 2015-17615
Organisme : Fondazione del Monte di Bologna e Ravenna
ID : N/A
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