CaMKK2 in myeloid cells is a key regulator of the immune-suppressive microenvironment in breast cancer.
Animals
Breast Neoplasms
/ genetics
CD8-Positive T-Lymphocytes
/ immunology
Calcium-Calmodulin-Dependent Protein Kinase Kinase
/ antagonists & inhibitors
Carcinoma
/ genetics
Cell Proliferation
Chemokines
/ immunology
Female
Humans
Immunohistochemistry
In Vitro Techniques
Macrophages
/ immunology
Mammary Neoplasms, Animal
/ genetics
Mice
Mice, Knockout
Mice, Transgenic
Myeloid Cells
/ immunology
Triple Negative Breast Neoplasms
/ genetics
Tumor Escape
/ genetics
Tumor Microenvironment
/ immunology
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
04 06 2019
04 06 2019
Historique:
received:
04
11
2017
accepted:
09
05
2019
entrez:
6
6
2019
pubmed:
6
6
2019
medline:
18
6
2019
Statut:
epublish
Résumé
Tumor-associated myeloid cells regulate tumor growth and metastasis, and their accumulation is a negative prognostic factor for breast cancer. Here we find calcium/calmodulin-dependent kinase kinase (CaMKK2) to be highly expressed within intratumoral myeloid cells in mouse models of breast cancer, and demonstrate that its inhibition within myeloid cells suppresses tumor growth by increasing intratumoral accumulation of effector CD8
Identifiants
pubmed: 31164648
doi: 10.1038/s41467-019-10424-5
pii: 10.1038/s41467-019-10424-5
pmc: PMC6547743
doi:
Substances chimiques
Chemokines
0
CAMKK2 protein, human
EC 2.7.11.17
Calcium-Calmodulin-Dependent Protein Kinase Kinase
EC 2.7.11.17
Camkk2 protein, mouse
EC 2.7.11.17
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
2450Subventions
Organisme : Susan G. Komen (Susan G. Komen Breast Cancer Foundation)
ID : IIR13264868
Pays : International
Organisme : U.S. Department of Health & Human Services | National Institutes of Health (NIH)
ID : R01CA174643
Pays : International
Organisme : United States Department of Defense | United States Army | U.S. Army Corps of Engineers (US Army Corps of Engineers)
ID : CA140307
Pays : International
Organisme : NIH HHS
ID : S10 OD018164
Pays : United States
Organisme : U.S. Department of Health & Human Services | National Institutes of Health (NIH)
ID : R00CA172357
Pays : International
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